专利号:US-10766863-B2 优先权日:2014-11-17 标 题 :Monocarboxylate transport modulators and uses thereof 发明人:SANDANAYAKA VINCENT; WU QIONG 权利人:NIROGYONE THERAPEUTICS INC 摘要:The invention generally relates to the field of monocarboxylate transport modulators, e.g., monocarboxylate transport inhibitors, and more particularly to new substituted-quinolone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in treating, modulating, forestalling and/or reducing physiological conditions associated with monocarboxylate transport activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, obesity, diabetes, cardiovascular diseases, tissue and organ transplant rejection, and malaria.
专利号:US-9701686-B2 优先权日:2009-12-04 标题:Tricyclopyrazole derivatives 发明人:DISINGRINI TERESA; MANTEGANI SERGIO; VARASI MARIO 权利人:NERVIANO MEDICAL SCIENCES SRL 摘要:Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
专利号:CN-118561738-A 优先权日:2024-05-09 标题 :Synthesis method of 3-indolone