CAS: 571170-77-9; (R)-2-(4-(4-Chlorobenzyl)-7-Fluoro-5-(Methylsulfonyl)-1,2,3,4-Tetrahydrocyclopenta[b]Indol-3-yl)Acetic Acid

上下游产品

(E)-2-(4-(4-Chlorobenzyl)-7-Fluoro-5-(Methylsulfonyl)-1,2-Dihydrocyclopenta[b]Indol-3(4H)-Ylidene)Acetic Acid 866215-99-8
(E)-2-(4-(4-氯苄基)-7-氟-5-(甲基磺酰基)-1,2-二氢环戊并[b]吲哚-3(4H)-基)乙酸 2-[4-[(4-Chlorophenyl)Methyl]-7-Fluoro-5-Methylsulfonyl-1,2-Dihydrocyclopenta[b]Indol-3-Ylidene]Acetic Acid 866215-99-8
[(3R)-5-Bromo-4-(4-Chlorobenzyl)-7-Fluoro-1,2,3,4-Tetrahydrocyclopenta[b]Indol-3-Yl]Acetic Acid 393509-05-2
[4-(4-Chlorobenzyl)-7-Fluoro-5-Bromo-1,2,3,4-Tetrahydrocyclopenta[b]Indol-3-Yl]Acetic Acid 393509-04-1
2-(5-溴-7-氟-1,2,3,4-四氢环戊并b吲哚-3-基)乙酸 (5-Bromo-7-Fluoro-1,2,3,4-Tetrahydrocyclopenta[b]Indol-3-yl)Acetic Acid 393509-23-4
7-氟-5-溴-1,2,3,4-四氢乙酯 Ethyl (7-Fluoro-1,2,3,4-Tetrahydrocyclopenta[b]Indol-3-yl)Acetate 393509-21-2
2-(7-氟-1,2,3,4-四氢环戊并b吲哚-3-基)乙酸 2-(7-Fluoro-1,2,3,4-Tetrahydrocyclopenta[b]Indol-3-yl)Acetic Acid 393509-22-3
(2As,9Bs,9Cs)-6-Bromo-8-Fluoro-2A,3,9B,9C-Tetrahydro-4H-Benzo[b]Cyclopenta[gh]Pyrrolizin-4-One 828932-44-1

Methyl 2-[(3R)-4-(4-Chlorobenzyl)-7-Fluoro-5-(Methylsulfonyl)-1,2,3,4-Tetrahydrocyclopenta[b]Indol-3-Yl]Acetate置于sodium Hydroxide体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 2.0H,以604 Mg的收率获得产物拉罗皮兰
参考文献:前列腺素d 2受体拮抗剂的不对称合成
标题:前列腺素d 2受体拮抗剂的不对称合成
摘要:开发了一种不对称合成物,用于生产前列腺素d 2受体拮抗剂,用于治疗变应性鼻炎.使用不对称烯丙基烷基化化学方法设定立体异构中心,并通过pd催化的n-环化/ Heck方法构建结构的核心.合成依赖于后期的二氢吲哚氧化,不会使产物外消旋.
DOI:10.1021/jo048305+

专利信息

专利号:US-9750749-B2
优先权日:2010-05-03
标题 :Methods of treating thyroid eye disease
发明人：PHIPPS RICHARD P; GUO NAXIN; FELDON STEVEN
权利人:PHIPPS RICHARD P; GUO NAXIN; FELDON STEVEN; UNIV ROCHESTER
摘要:The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid eye disease an agent that interferes with hyaluronan synthesis in an amount that is effective to inhibit hyaluronan synthesis in a retro-ocular space. The pharmaceutical compositions that includes a carrier suitable for ophthalmic delivery and an agent that interferes with hyaluronan synthesis. Combination therapies are also disclosed.

专利号:US-7612106-B2
优先权日:2004-12-23
标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
发明人：BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU
权利人:ARENA PHARM INC
摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

专利号:CN-117645564-A
优先权日:2022-12-02
标 题 :A kind of fluoroalkyl substituted indole derivative and its synthesis method and application

专利号:CN-115925611-A
优先权日:2022-12-02
标题 :A kind of fluoroalkyl substituted indole derivative and its synthesis method