CAS: 5619-04-5; H-Dl-Ser-Ome.Hcl

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CAS号67-56-1 甲醇 | CAS号302-84-1 DL-丝氨酸 | CAS号33646-31-0 DL-3-氯丝氨酸甲酯盐酸盐 | CAS号17136-54-8 S-3-氯丝氨酸甲酯盐酸盐 | CAS号35356-70-8 2-乙酰胺基丙烯酸甲酯 | CAS号81629-69-8 methyl 2-(diace... | CAS号56-45-1 L-丝氨酸 | CAS号2104-89-4 2-氨基-3-羟基丙酸甲酯 | CAS号155884-28-9 4,5-二氢-2-甲基-1,3... | CAS号13515-76-9 N-(三苯基甲基)-DL-丝氨酸甲酯 | CAS号14464-15-4 N-Cbz-DL-丝氨酸甲酯 | CAS号69942-12-7 N-B°C-DL-丝氨酸甲酯

甲醇,Dl-丝氨酸置于氯化亚砜体系中,化学反应 1.0H,以1.6 G的收率获得产物dl-丝氨酸甲酯盐酸盐
参考文献:Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly,Hydrogel Characterization,And Evaluation As Potential Drug Nanocarriers
标题:Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly,Hydrogel Characterization,And Evaluation As Potential Drug Nanocarriers
摘要:在这项工作中,我们介绍了含有色氨酸,N端以非甾体抗炎药萘普生封端,C端为脱水氨基酸(脱水苯丙氨酸(δphe),脱水氨基丁酸(δabu)和脱水丙氨酸(δala))的二肽,这些二肽作为有效的蛋白酶抵抗型水凝胶形成剂.我们报告了最佳凝胶化条件.透射电子显微镜实验揭示,水凝胶由通过肽自组装形成的微/纳米尺寸纤维网络组成.荧光光谱和圆二色光谱表明,自组装过程是由芳香族基团的堆积相互作用驱动的.萘普生部分的萘环在纤维中通过手性堆积高度有序.流变学实验证明,最疏水的肽(含c端δphe)在较低的临界凝胶化浓度下形成了更具弹性的凝胶.这种凝胶显示出不可逆的破碎,而c端δabu和δala凝胶虽然弹性较差,但表现出结构恢复和部分弹性性能的愈合.将一种潜在的抗肿瘤噻吩并[3,2-B]吡啶衍生物(非共价地)掺入含c端δphe残基的凝胶形成剂形成的水凝胶中.荧光和福斯特共振能量转移测量表明,药物位于疏水环境中,靠近/与肽纤维相连,这表明这种类型的水凝胶是一个非常好的药物纳米载体候选者.
DOI:10.1021/acs.Biomac.5B01006

专利信息

专利号:US-4906767-A
优先权日:1987-06-30
标题:Monomers with urea groups
发明人：MATHIAS LON J; KURZ DAVID W
权利人:UNIV SOUTHERN MISSISSIPPI
摘要:There is disclosed a family of new vinyl monomers capable of forming polymers by free radical polymerization. The vinyl monomer is of the formula ##STR1## wherein R 1 and R 2 are substituted or unsubstituted hydrocarbons, X is O, NH or NR 3 , and R 3 is substituted or unsubstituted hydrocarbon. n The intermediates in the synthesis of these monomers are new beta-chloroalanine ureas. The polymers are useful in film and fiber formation and display good toughness. These new vinyl monomers also form a cyclic monomer.

专利号:US-2010249192-A1
优先权日:2007-12-11
标 题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LI CHUN SING; RAMTOHUL YEEMAN K; LECLERC JEAN-PHILIPPE
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. n HetAr − W − X − Ar  (I)

专利号:US-9192612-B2
优先权日:2013-02-13
标题:Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; BECK ELIZABETH MARY; DAVOREN JENNIFER ELIZABETH; LACHAPELLE ERIK ALPHIE; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 and R 2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-4871736-A
优先权日:1986-11-25
标 题:Stereoisomeric tricyclic bis(dioxopiperazines) and pharmaceutical compositions
发明人：NAIR RAGHUNATHAN V; WITIAK DONALD T
权利人:UNIV OHIO STATE
摘要:Stereoisomeric tricyclic bis(dioxopiperazines) of the formula wherein R is H or and the processes for the synthesis thereof are provided. The compounds are effective as antitumor or antimetastatic drugs.

专利号:RU-2174511-C2
优先权日:1996-07-23
标 题 :Amides of alpha-amino acids, their synthesis and therapeutic use