CAS: 552-62-5; 7-Methyl-3,7-Dihydro-1H-Purine-2,6-Dione

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CAS号64995-73-9 3-benzyl-7-meth... | CAS号1021187-29-0 2,6-dibenzylthi... | CAS号72816-88-7 6-氨基-1-苄基-5-甲基氨基尿嘧啶 | CAS号2273-93-0 2,6-二氯-7-甲基嘌呤 | CAS号5440-17-5 6-氯-7-甲基嘌呤 | CAS号38917-24-7 6-methoxy-7-met... | CAS号85982-51-0 6-methoxy-7-met... | CAS号85982-53-2 7-methyl-2-hydr... | CAS号7664-41-7 氨 | CAS号74-89-5 氨基甲烷 | CAS号57-13-6 尿素 | CAS号61066-33-9 pyrimidine-2,4,... | CAS号598-50-5 甲基脲 | CAS号612-37-3 7-甲基尿酸 | CAS号33403-02-0 7-methyl-3H-pur... | CAS号107-97-1 肌氨酸 | CAS号2273-93-0 2,6-二氯-7-甲基嘌呤

📜3-Benzyl-7-Methyl-1H-Purine-2,6(3H,7H)-Dione置于三氯化铝体系中,用 甲苯 作为反应溶剂,化学反应 1.0H,以75%的收率获得产物7-甲基黄嘌呤
参考文献:咪唑并[2,1-I]嘌呤-5-酮和相关三环水溶性嘌呤衍生物:有效的 A(2A)-和 A(3)-腺苷受体拮抗剂.
标题:咪唑并[2,1-I]嘌呤-5-酮和相关三环水溶性嘌呤衍生物:有效的 A(2A)-和 A(3)-腺苷受体拮抗剂.
摘要:一系列由黄嘌呤衍生物衍生的三环咪唑并[2,1-I]嘌呤酮和扩环类似物已被制备作为腺苷受体(ar)拮抗剂.与黄嘌呤相比,三环化合物由于碱性氮原子在生理条件下可以质子化而表现出更高的水溶性.引入的取代基分别赋予 A(2A) 或 A(3) Ar 较高的亲和力.开发了一种新的毛细管电泳方法,使用天然和改性 β-环糊精作为手性鉴别剂来测定选定手性产物的对映体纯度.这些化合物在大鼠脑 A(1) 和 A(2A) Ar 的放射性配体结合测定中进行了研究.另外,还对选定的化合物进行了人重组 A(3) Ar 的放射性配体结合测定以及大鼠脂肪细胞膜的 A(1) Ar,大鼠 Pc 12 细胞膜的 A(2A) Ar 的功能研究(腺苷酸环化酶测定),和小鼠 Nih 3T3 细胞膜的 A(2B) Ar.结构-活性关系与相应的黄嘌呤衍生物相似.与 8-苯乙烯基黄嘌呤衍生物相比,2-苯乙烯基咪唑嘌呤酮对 A(2A) Ar 的效力较低.
DOI:10.1021/jm011093D

专利信息

专利号:US-5905091-A
优先权日:1996-07-03
标 题 :Enhancement of skin pigmentation by prostaglandins
发明人：FULLER BRYAN B
权利人:UNIV OKLAHOMA
摘要:A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.

专利号:US-2024317750-A1
优先权日:2021-06-24
标 题 :An Efficient Process for the Synthesis of Methylliberine and Polymorphs Thereof
发明人：KANUMURU RAHUL RAJU; SHAJI GEORGE KOCHUMALAYIL; VANA MURALI MOHANARAO; SURANENI RAVIKUMAR; ANINDYA SIL
权利人:FERTIS INDIA PVT LTD
摘要:The present invention discloses a synthetic procedure for the preparation of Methylliberine and its polymorphs thereof in a simple and efficient manner.

专利号:US-6569683-B1
优先权日:1998-05-29
标题 :Use of oxidative stress diagnostic plot as a health indicator for assessing oxidative stress and its control in humans
发明人：OCHI HIROTOMO; CUTLER RICHARD G
权利人:NIKKEN FOODS CO LTD
摘要:A diagnostic plot derived from the measurement of 82 assays which characterize two key parameters which significantly contribute to an individual's health status. These two parameters are oxidative stress profile (OSP) and antioxidant profile. Each of the assays which constitute the 82 assays are complimentary with other assays of the profile, thus providing either confirmation information or the synthesis of new information. The diagnostic plot, developed to interpret the assay data which provides information about oxidative damage and antioxidant protection, consists of four quadrants, each with noticeable characteristics. By visually assessing the position of a patient's OSP status, in comparison to reference OSP values in the four quadrants constituting the diagnostic plot, physicians and other health care professionals can provide sound advice to their patients regarding dietary and life style changes one need to adhere for prevention of oxidative stress-related diseases as well as postponing premature aging processes.

专利号:US-4568676-A
优先权日:1983-11-25
标题:Method of inhibiting aggregation using thromboxane synthetase inhibitor in combination with a cyclic AMP phosphodiesterase inhibitor
发明人：SMITH J BRYAN
权利人:UNIV JEFFERSON
摘要:A novel method of inhibiting blood platelet aggregation is disclosed which comprises the use of a CAMP inhibitor together with an inhibitor of thromboxane synthesis. While inhibitors of thromboxane synthesis are only weak inhibitors of platelet aggregation, the addition of only a small amount of a CAMP inhibitor has been found to result in a synergistic increase in the degree of platelet aggregation resulting from such combined additions. Marked increases over the otherwise expected culumative effects of these inhibitors have been demonstrated using combination of various thromboxane synthetase inhibitors and various CAMP inhibitors.

专利号:US-5628987-A
优先权日:1989-12-15
标题 :Pigmentation enhancer and method
发明人：FULLER BRYAN B
权利人:UNIV OKLAHOMA
摘要:A composition for increasing synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation. An organ culture system comprising viable human foreskin samples which may be used to test the effects of agents on human skin, including pigmentation enhancers on human skin.

专利号:CN-114686493-B
优先权日:2022-04-25
标 题:CsJAZ12 gene and application thereof in regulating and controlling synthesis of tea caffeine