CAS: 532-48-9; Euparin

该化合物是一种化学化合物,属于抗凝胶剂类别,特别是一种肝素,主要用于抗凝胶性能,有助于防止血凝血块形成;Euparin的特点是有能力加强抗血清三世的活动,从而抑制血清三世和Xa系数,这是凝胶层中的关键成分;这在医疗应用中具有价值,特别是在血栓栓栓塞失调的预防和治疗方面.该化合物通常通过注射进行,因为口服生物利用率低.就物理特性而言,Euparin是水中可溶解的白色和非白色粉剂,便于在各种配方中使用.安全性和效率在应用中至关重要,对于监测病人潜在副作用,例如出血并发症,至关重要.

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上下游产品

CAS号89-84-9 2',4'-二羟基苯乙酮 | CAS号22877-01-6 1-(2,4-双(苄氧基)苯基)乙酮 | CAS号62069-33-4 1-(2,4-dihydrox... | CAS号173992-03-5 5'-iodo-2',4'-b... | CAS号62069-34-5 1-(2,4-dihydrox... | CAS号56964-06-8 copper(1+),2-me... | CAS号34293-13-5 1-(6-methoxy-2-...

合成工艺路线路线简述

    📜1-(2,4-二羟基-5-碘苯基)乙酮置于palladium Dichloride Copper(L) Iodide,三溴化硼,Potassium Carbonate,三苯基膦体系中,用 甲醇,二氯甲烷,三乙胺,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 2.43H,反应生成 泽兰素
    参考文献:Sogawa,Akihiro; Tsukayama,Masao; Nozaki,Hiroshi,Heterocycles,1996,Vol. 43,# 1,P. 101-111
    标题:Sogawa,Akihiro; Tsukayama,Masao; Nozaki,Hiroshi,Heterocycles,1996,Vol. 43,# 1,P. 101-111

    海关参考信息

    专利信息


    专利号:US-4230624-A
    优先权日:1977-09-02
    标 题 :Process for the synthesis of derivatives of the benzofuran, chromene and isochromene type
    发明人：LE CORRE MAURICE; HERCOUET ALAIN; BEGASSE BEATRICE
    权利人:ANVAR
    摘要:The invention relates to a process for the production of therapeutic compounds of the benzofuran, chromene and isochromene type of the general formula; in which formula, R1 and R3=H, lower alkyl, aralkyl or cycloalkyl R2=H or an organic radical and when D= R1 and R3 may represent an organic radical. The process comprising the cyclization in the liquid phase and in the presence of a base a compound of the formula; in which formula; R'=an alkyl, aryl or aralkyl radical and X-=an anion.

    专利号:IE-47741-B1
    优先权日:1977-09-02
    标 题:Process for the synthesis of derivatives of the benzofuran,chromene and isochromene type

    专利号:CH-638511-A5
    优先权日:1977-09-02
    标题:PROCESS FOR THE SYNTHESIS OF OXYGEN HETEROCYCLES.

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    主要参考文献


    1: Han XM, Huang F, Jiao ML, Liu HR, Zhao ZH, Zhan HQ, Guo SY. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 1;43(10):1490-1500. doi: 10.1248/bpb.b20-00093. Epub 2020 Aug 13. 33(11):1617-1623. doi: 10.1080/14786419.2018.1428598. Epub 2018 Jan 28.
    2013:402364. doi: 10.1155/2013/402364. Epub 2013 Jul 17.
    4: Mohammadi M, Yousefi M, Habibi Z, Dastan D. Chemical composition and antioxidant activity of the essential oil of aerial parts of Petasites albus from Iran: a good natural source of euparin. Nat Prod Res. 2012;26(4):291-7. doi: 10.1080/14786410903374819. Epub 2011 Jul 11. 24(1):81-91. doi: 10.1007/s11030-019-09935-6. Epub 2019 Mar 4. 34(7):923-929. doi: 10.1080/14786419.2018.1542389. Epub 2018 Dec 26. 24(19):1854-60. doi: 10.1080/14786419.2010.482935. 31(11):1325-1328. doi: 10.1080/14786419.2016.1239091. Epub 2016 Oct 6. 11(3):427-37. doi: 10.1002/cbdv.201300323. 53(12):1555-8. doi: 10.1248/cpb.53.1555.

    合成参考文献


    摘要:Shaabani, A.; Sarvary, A.; Shaabani, S., Science of Synthesis: Multicomponent Reactions, (2013) 2, 103.
    参考文献:10.1021/np960199m
    摘要:Castañeda P, Gómez L, Mata R, Lotina-Hennsen B, Anaya AL, Bye R. Phytogrowth-inhibitory and antifungal constituents of Helianthella quinquenervis. J Nat Prod. 1996 Mar;59(3):323–6. doi: 10.1021/np960199m.
    参考文献:10.1038/nchem.1506
    摘要:Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem. 2013 Jan;5(1):21–8. doi: 10.1038/nchem.1506.
    参考文献:10.1248/bpb.b20-00093
    摘要:Han XM, Huang F, Jiao ML, Liu HR, Zhao ZH, Zhan HQ, Guo SY. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 01;43(10):1490–500. doi: 10.1248/bpb.b20-00093.
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