CAS: 514-36-3; Fludrocortisone Acetate

上下游产品

CAS号4383-30-6 21-乙酰氧基-9Β,11Β-... | CAS号566-35-8 11-表氢化可的松 | CAS号7753-60-8 δ-9(11)-氢化可的松醋酸酯 | CAS号50733-54-5 9-Bromo-11,17,2... | CAS号113862-93-4 21-Acetoxy-17α-... | CAS号67-66-3 氯仿 | CAS号7664-39-3 氟化氢 | CAS号338-98-7 醋酸异氟泼尼松 | CAS号338-95-4 异氟泼尼松 | CAS号127-31-1 氟氢可的松

9β,11β-Epoxy-17α-Hydroxypregna-4-Ene-3,20-Dione-21-Acetate置于氟化氢吡啶体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以57.4%的收率获得产物醋酸氟氢可的松
参考文献:一种氟氢可的松醋酸酯的制备方法
标题:一种氟氢可的松醋酸酯的制备方法
摘要:本发明涉及一种氟氢可的松醋酸酯的制备方法,包括:9β,11β‑环氧‑17α‑羟基孕甾‑4‑烯‑3,20‑二酮‑21‑醋酸酯与氟化试剂进行开环反应,其中所述氟化试剂为氟化氢的有机胺盐或溶液.本发明重点改良了关键工艺步骤环氧化合物开环氟化的试剂及条件,以氟化氢的有机胺盐代替高毒性,高腐蚀性的氟化氢气体,操作安全方便,氟化试剂用量少,适合工业生产.

专利信息

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人：BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-8926955-B2
优先权日:2008-12-22
标题 :Synthesis of polymer conjugates of indolocarbazole compounds
发明人：BAGNOD RAFFAELLA; BECCARIA LUCA; BERTARIONE RAVA ROSSA LUISA; CRISCUOLO DOMENICO; LORENZETTO CHIARA; MAINERO VALENTINA; MARCONI ALESSANDRA; PINCELLI CARLO; TRAVERSA SILVIO
权利人:BAGNOD RAFFAELLA; BECCARIA LUCA; BERTARIONE RAVA ROSSA LUISA; CRISCUOLO DOMENICO; LORENZETTO CHIARA; MAINERO VALENTINA; MARCONI ALESSANDRA; PINCELLI CARLO; TRAVERSA SILVIO; CREABILIS S A
摘要:The present invention relates to a process for the preparation of polymer conjugates of indolocarbaxole compounds, in particular of polymer conjugates of K-252a and derivatives thereof, by a synthetic route which results in a highly pure product, with a high product yield. In a further aspect the present invention relates to novel polymer conjugates of K-252a and derivatives thereof, wherein the chemical group linking the polymer unity to the K-252a or to the K-252a derivative compound is characterized by a 5-member oxazolidindionic cyclic structure. These novel polymer conjugates are obtained through the novel synthetic route with high purity and high yields.

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:WO-2024232849-A1
优先权日:2023-05-10
标 题:A pharmaceutical composition for increasing melanin synthesis in hair follicles
发明人：BALKAN GURSES NAZ DICLE; TULUNAY MAHIR
权利人:IFL PHARMA ILAC SANAYI VE TICARET ANONIM SIRKETI
摘要:The present invention relates to a pharmaceutical composition that is developed to convert white body hair, particularly hair, back to its original color. Particularly, the invention relates to a composition that works based on the increasing mechanism of melanin synthesis by regulating melanocyte cells. The pharmaceutical composition of the present invention is applied to the scalp via an intradermal method.

专利号:US-2021244638-A1
优先权日:2018-06-05
标 题:Inhibitors of glycosphingolipid synthesis and methods of use
发明人：CHATTERJEE SUBROTO B
权利人:SUBROTO B CHATTERJEE
摘要:Compositions in the prevention and treatment of skin diseases or associated disorders, inflammation or inflammatory diseases or disorders, include at least one inhibitor of glycosphingolipid synthesis.