CAS: 472-11-7; Ruscogenin

该化合物是一种天然的血清素,产自植物精液鲁斯库斯(俗称屠夫的扫帚),其特点是分子结构,包括一种含有糖味的类固醇脊椎,有助于其盐碱的分类.Ruscogenin展示了各种生物活动,包括抗炎,抗氧化剂和血管保护效应,使其对药理研究感兴趣.其行动机制往往包括调节细胞信号路径,这可以影响血管健康和减少水肿.此外,Ruscogenin已经研究过其治疗慢性静脉不全和肝红血素等条件的潜力.该化合物通常从植物来源提取,并可用于草药和补充营养剂.由于其生物活性特性,Ruscogenin还因其在各种健康条件下的潜在治疗用途而受到调查,尽管需要进一步研究以充分阐明其功效和安全性.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

spirosta-5(6),25(27)-diene-1β,3β-diol spirost-5-ene-1-oxo-3β-ol ophiopogonin B 2)-4-O-sulfo-β-D-arabinopyranoside(25R)-ruscogenin 1-O-α-L-rhamnopyranosyl-(1-2)-4-O-sulfo-β-D-arabinopyranosideruscogenin acetate 25(S)-ruscogenin diacetate 25(S)-ruscogenin 1,3-diacetate 25(S) ruscogenin

合成工艺路线路线简述

  • 合成目标产物 Ruscogenin 主要起始原料 Neoruscogenin
  • (文献来源)合成步骤主要原料 Neoruscogenin
(25R)-1-O-[2-O-(α-L-Rhamnopyranosyl)-α-L-Arabinopyranosyl]-26-O-(β-D-Glucopyranosyl)Furost-5,20(22)-Dien-1β,3β,26-Triol置于β-Glucosidase体系中,用 磷酸 作为反应溶剂,化学反应 24.0H,反应生成 鲁斯可皂苷元
参考文献:来自 Ruscus Ponticus 的甾体苷
标题:来自 Ruscus Ponticus 的甾体苷
摘要:基于高效液相色谱与电喷雾正离子化多级离子阱质谱联用,通过 HPLC-Esims(N) 方法获得了木皮地下部分和叶子的比较代谢物分析.仔细研究每个色谱峰的 HPLC-Esims(N) 碎裂模式,特别是诊断性子离子的鉴定,使我们能够快速筛选属于不同类别的皂苷,例如脱水/或非呋甾烷醇,螺甾烷醇和孕烷苷,并及时突出两个植物部分之间的异同.这种方法,然后通过 1D 和 2D NMR 实验进行分离和结构解析,导致从地下部分鉴定了 11 种皂苷,其中两种脱水呋喃甾醇苷和一种新的vespertilin衍生物,以及来自r. Ponticus叶子的九种皂苷,以前从未报道过.所取得的结果突出了在 R. Ponticus 叶子中而不是在植物的地下部分中呋甾醇糖苷衍生物的普遍存在,这显示出更广泛的结构多样性.特别是,首次从 Ruscus 物种中分离出脱水呋喃烷醇衍生物是一个不寻常的发现,这使得 R. Ponticus
DOI:10.1016/j.Phytochem.2011.01.033

海关参考信息

专利信息


专利号:GB-878693-A
优先权日:1958-03-21
标题:Synthesis of í~-pregnadiene-17 ª-, 21-diol-3, 20-dione

专利号:EP-0728471-B1
优先权日:1995-02-24
标题 :Cosmetic compositions for enhancing the collagen synthesis of the skin

专利号:US-7678380-B2
优先权日:1996-11-07
标 题 :Cosmetic treatment method for fighting against skin ageing effects
发明人:BONTE FREDERIC; DUMAS MARC; HEUSELE CATHERINE; LE BLAY JACQUES
权利人:LVMH RECH
摘要:The present invention relates to a method of cosmetic treatment for combating the effects of skin ageing and to novel cosmetic compositions which are particularly suitable for carrying it out. According to the invention, at least one agent for promoting the adhesion of the keratinocytes of the epidermal basal layer to the dermo-epidermal junction, especially to the collagen IV of said junction, such as, in particular, a divalent metal salt or complex, preferably magnesium aspartate or magnesium chloride, is used, optionally in association with a stimulant of collagen IV synthesis and/or a stimulant of collagen VII synthesis.

专利号:BR-112016022455-B1
优先权日:2014-03-31
标 题 :use of a supernatant from cultures of a strain of bacillus pumilus species, unnatural cosmetic or dermopharmaceutical composition; skin, stimulate collagen synthesis and / or hyaluronic acid synthesis, treatment of skin tightening and / or prevention of loss of skin firmness

专利号:US-2004146539-A1
优先权日:2003-01-24
标 题:Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits
发明人:GUPTA SHYAM K
摘要:I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA/UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, “love handlesâ€? in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery ystem.

专利号:US-7427690-B2
优先权日:2004-06-05
标 题 :Multifunction “crown complexesâ€? from amino acids and peptides for skin and hair restoration
发明人:GUPTA SHYAM K
权利人:BIODERM RESEARCH
摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.
长沙捷凯生物制品有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.gentcare.com
电话: 0731-82287663👤
📞长沙捷凯生物制品有限公司 ⚠️参考联系方式

销售电话:0731-82287663
邮箱:naturalextract@vip.163.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Qi JY, Jin YC, Wang XS, Yang LK, Lu L, Yue J, Yang F, Liu YS, Jiang YL, Song DK, Lv T, Li XB, Zhang K, Liu SB. Ruscogenin Exerts Anxiolytic-Like Effect via Microglial NF-κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain. Phytother Res. 2024 Sep 12. doi: 10.1002/ptr.8325. Epub ahead of print.
225:114173. doi: 10.1016/j.phytochem.2024.114173. Epub 2024 Jun 6. 12(5):989. doi: 10.3390/biomedicines12050989.
4: Wang RY, Wang MG, Tang HZ, Du H, Luo Y, Li Q, Zhang XH, Fu J, Lv CZ. The Protective Effects of Ruscogenin Against Lipopolysaccharide-Induced Myocardial Injury in Septic Mice. J Cardiovasc Pharmacol. 2024 Aug 1;84(2):175-187. doi: 10.1097/FJC.0000000000001563.

合成参考文献


摘要:Huang BM, Yao CW, Bian QQ, Wang ZG, Mo JY. [Determination of diosgenin and ruscogenin in Radix Ophiopogonis by nonaqueous capillary electrophoresis]. Yao Xue Xue Bao. 2011 Apr;46(4):443–6.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知