CAS: 445-28-3; 2-Fluorobenzamide

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CAS号394-47-8 2-氟苯甲腈 | CAS号389-31-1 2-氟-DL-扁桃酸 | CAS号24652-66-2 (E)-2-氟苯甲醛肟 | CAS号446-52-6 邻氟苯甲醛 | CAS号75-64-9 叔丁胺 | CAS号445-29-4 邻氟苯甲酸 | CAS号766-49-4 1-乙炔-2-氟苯 | CAS号66896-69-3 N-allyl-2-fluor... | CAS号57-13-6 尿素 | CAS号443-26-5 邻氟苯甲酸乙酯 | CAS号394-47-8 2-氟苯甲腈 | CAS号348-54-9 邻氟苯胺 | CAS号446-24-2 2-氟亚苯基肼 | CAS号446-22-0 2-氟苯丙酮 | CAS号399-31-5 2-氟乙酰苯胺 | CAS号75907-82-3 2-氟苯甲酰硫胺 | CAS号16198-97-3 2,3-dihydro-1H-... | CAS号16664-12-3 methyl N-(2-flu... | CAS号72084-13-0 2-Phenoxybenzamide | CAS号67829-54-3 8,9,10,11-tetra...

2-氟苯腈置于[ru(Otf){η6:K1(P)-Pph2-Binaphthyl}{pph2(Oh)}][otf]体系中,用 水 作为反应溶剂,化学反应 5.0H,以83%的收率获得产物2-氟苯甲酰胺
参考文献:基于二合一的羟基膦芳烃-钌(II)配合物作为腈水合催化剂的研究†
标题:基于二合一的羟基膦芳烃-钌(II)配合物作为腈水合催化剂的研究†
摘要:所述binap基于hydroxyphosphine-(η 6-Arene)-钌(II)配合物[rux {η 6:K 1(p)-Pph 2联萘} {pph 2(oh)}] [光学传递函数(x =光学传递函数(4),Cl(5))被评估为潜在的腈选择性水合成伯酰胺的催化剂.三氟甲磺酸酯衍生物4被证明是活性最高的,能够在100oc的纯水中水合多种芳香族,杂芳香族,α,β-不饱和和脂肪族腈.复杂4的效用还已经证明可以促进醛肟的催化重排.另外,给出了关于羟基膦配体pph 2(oh)在催化反应中所起的作用的见解.
DOI:10.1039/c4Ra12013B

专利信息

专利号:US-8506927-B2
优先权日:2011-01-05
标 题 :Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging
发明人：MACH ROBERT H; TU ZHUDE
权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON
摘要:Pegylated fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labeled with a positron-emitting radioisotope such as 18 F, can be used as radiotracers for medical imaging such as imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labeled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

专利号:US-8193360-B2
优先权日:2003-07-31
标 题:Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging
发明人：MACH ROBERT H; TU ZHUDE
权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON
摘要:Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18 F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:US-4713383-A
优先权日:1984-10-01
标 题:Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
发明人：FRANCIS JOHN E; GELOTTE KARL O
权利人:CIBA GEIGY CORP
摘要:[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N-R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N-R3.

专利号:US-2005124683-A1
优先权日:2003-09-17
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：ALEGRIA LARRY A; CANAN-KOCH STACIE S; DRESS KLAUS R; HUANG BUWEN; KUMPF ROBERT A; LEWIS KATHLEEN K; MATTHEWS JEAN J; SAKATA SYLVIE K; VIRGIL SCOTT C
权利人:AGOURON PHARMA
摘要:The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis

专利号:US-9174999-B2
优先权日:2009-05-07
标题:Methods and compositions for studying, imaging, and treating pain
发明人：DU BOIS JUSTIN; MULCAHY JOHN; ANDRESEN BRIAN; YEOMANS DAVID C; BISWAL SANDIP
权利人:DU BOIS JUSTIN; MULCAHY JOHN; ANDRESEN BRIAN; YEOMANS DAVID C; BISWAL SANDIP; UNIV LELAND STANFORD JUNIOR
摘要:Saxitoxin analog compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogs, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analog binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject. n In embodiments, the present disclosure provides a method for alleviating pain in a subject in need of treatment, the method comprising administering to the subject an effective amount of a saxitoxin analog compound, or a pharmaceutically acceptable salt, isomer, tautomer or prodrug thereof, whereby pain in said subject is alleviated.