CAS: 3616-56-6; 2,2-Diethoxy-N,N-Dimethylethanamine

相似化合物

20677-73-0 38711-20-5 69148-92-1

上下游产品

CAS号124-40-3 二甲胺 | CAS号2032-35-1 2-溴-1,1-二乙氧基乙烷 | CAS号621-62-5 氯乙醛缩二乙醇 | CAS号19289-58-8 N,N,N',N'-tetra... | CAS号850140-72-6 阿法蒂尼(BIBW2992) | CAS号698387-09-6 来那替尼 | CAS号6711-89-3 Ethanaminium,2,... | CAS号13717-24-3 alpha,alpha-bis... | CAS号111296-91-4 5,12-二氢吲哚并[3,2-a]咔唑

(2,2-Diethoxy-Ethyl)-Dimethyl-Propyl-Ammonium; Iodide 反应生成 二甲氨基乙醛缩二乙醇
参考文献:Stoermer; Prall,Chemische Berichte,1897,Vol. 30,P. 1514
标题:Stoermer; Prall,Chemische Berichte,1897,Vol. 30,P. 1514

专利信息

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:EP-3089961-B1
优先权日:2013-12-31
标 题:Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:EP-3089961-A1
优先权日:2013-12-31
标题 :Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:US-2015183764-A1
优先权日:2013-12-31
标 题 :Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:WO-2015101554-A1
优先权日:2013-12-31
标 题:Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:US-8188274-B2
优先权日:2006-01-26
标题 :Process for preparing aminocrotonylamino-substituted quinazoline derivatives
发明人：SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA
权利人:SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA; BOEHRINGER INGELHEIM INT
摘要:The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) n nwherein the groups R a , R b , R c and R d have the meanings given in the claims, as well as sulphonyl derivatives of formulan n nand the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.