CAS: 209984-57-6; (S)-2-((S)-2-(3,5-Difluorophenyl)-2-Hydroxyacetamido)-N-((S)-5-Methyl-6-Oxo-6,7-Dihydro-5H-Dibenzo[b,D]Azepin-7-yl)Propanamide

上下游产品

7-(S)-(L-Alaninyl)-Amino-5-Methyl-5,7-Dihydro-6H-Dibenz[b,D]Azepin-6-One

📜3,5-二氟苯甲醛置于n-碘代丁二酰亚胺,Cu(O-I-Bz)2*h2O,四磷十氧化物,Benzotriazol-1-Yloxyl-Tris-(Pyrrolidino)-Phosphonium Hexafluorophosphate,水,双氧水,氧气,Potassium Carbonate,(S,S)-(-)-2,2'-异亚丙基双(4-叔丁基-2-恶唑啉),1-羟基苯并三唑,N,N-二异丙基乙胺,三氟乙酸,Lithium Hydroxide体系中,用 四氢呋喃,2-甲基四氢呋喃,二氯甲烷,氯仿,水,异丙醇 用作溶剂,化学反应 159.08H,反应生成(As)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[b,D]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-Alpha-羟基苯乙酰胺
参考文献:通过 Umpolung 酰胺合成对映选择性合成 α-氧酰胺
标题:通过 Umpolung 酰胺合成对映选择性合成 α-氧酰胺
摘要:α-氧酰胺是通过对映选择性合成制备的,使用的序列从溴硝基甲烷与醛的亨利加成开始,最后是 Umpolung 酰胺合成 (Umas).高对映体选择的关键是发现手性铜 (II) 双(恶唑啉) 催化剂的邻碘苯甲酸盐提供亨利加合物的两种非对映异构体,对映体过量,在含氧碳上同手性.总体而言,这种 α-氧基酰胺方法为几乎完全专注于 α-氧基羧酸的对映选择性合成的替代品提供了创新的补充.
Doi:10.1021/ja306225U

专利信息

专利号:US-6486350-B1
优先权日:1998-09-30
标 题:Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
发明人：AUDIA JAMES E; HYSLOP PAUL A; NISSEN JEFFREY S; THOMPSON RICHARD C; TUNG JAY S; TANNER LAURA I
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are biological reagents which comprise compounds that inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of beta-amyloid peptide.

专利号:EP-2546229-A1
优先权日:2011-07-15
标 题:Method for synthesising aminobiphenyls
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:UNIV FRIEDRICH ALEXANDER ER
摘要:The present invention describes a process for the synthesis of 2-aminobiphenyls and derivatives thereof. This method is inexpensive to carry out and based on selective implementation. Functionalized biphenyl compounds are of great interest in particular as pharmaceuticals and crop protection agents and as precursors of such active substances. The process for preparing a compound of formula 3 is characterized in that a compound of formula 1 is reacted with a compound of formula 2.