CAS: 19924-43-7; 2-(3-Methoxyphenyl)Acetonitrile

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间甲基苯甲醚置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 四氯化碳,乙醇,水 用作溶剂,化学反应 6.0H,反应生成3-甲氧基苯乙腈
参考文献:新型手性超分子配体phthalaphos的铑催化烯烃不对称加氢反应
标题:新型手性超分子配体phthalaphos的铑催化烯烃不对称加氢反应
摘要:设计并合成了19个包含邻苯二甲酸二酰胺基团(phthalaphos)的由二元醇衍生的手性单亚磷酸酯的文库.在铑催化的前手性脱氢氨基酯和酰胺的对映选择性氢化中筛选了这些新的配体.文库中的几个成员显示了对甲基2-乙酰氨基丙烯酸丙烯酸酯(6个配体产生> 97%ee),对甲基(z)-2-乙酰氨基肉桂酸甲酯(6个配体产生> 94%ee)和n-(1-P乙烯基乙烯基乙酰胺(9个配体给出了95%的ee),而只有极少数代表对具有挑战性和工业相关性的底物提供了高对映选择性n-(3,4-二氢萘-1-基)乙酰胺(一种情况下为96%ee)和甲基(e)-2-(乙酰氨基甲基)-3-苯基丙烯酸酯(99%ee)在一种情况下).在大多数情况下,新的配体比其结构上相关的单齿亚磷酸酯(它们没有能够进行氢键相互作用的官能团)更具活性和立体选择性.进行的控制实验和动力学研究使我们证明了phthalaphos配体的二酰胺基团涉及的氢
Doi:10.1002/chem.201102018

专利信息

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:AU-2008226820-A1
优先权日:2007-03-12
标题 :De novo synthesis of conjugates

专利号:CA-2679473-A1
优先权日:2007-03-12
标题:De novo synthesis of conjugates

专利号:US-4072716-A
优先权日:1971-12-24
标 题:Bicycloalkane derivatives
发明人：SAUER GERHARD; HAUSER HELMUT; HAFFER GREGOR; RUPPERT JUERGEN; EDER ULRICH; WIECHERT RUDOLF
权利人:SCHERING AG
摘要:Bicycloalkane derivatives of the formula ##STR1## WHEREIN N IS 1 OR 2, R 1 is lower alkyl, X is carbonyl or free or etherified hydroxymethylene, and Y is --S--R 2 , --SO m --R 2 , or ##STR2## wherein m is 1 or 2, R 2 is alkyl, R 3 is hydrogen or lower alkyl, R 4 is aliphatic acyl and Z is nitro, lower alkanoyl, lower alkylsulfinyl, or lower alkylsulfonyl are useful intermediates in the total synthesis of steroids. The compounds are prepared by reacting a corresponding compound lacking the CH 2 Y substituent with formaldehyde and a mercaptan or a sulfinic acid, followed if desired by oxidation and optional salt condensation.

专利号:US-4051188-A
优先权日:1971-12-24
标题 :Novel bicycloalkane derivatives and the production thereof
发明人：SAUER GERHARD; HAUSER HELMUT; HAFFER GREGOR; RUPPERT JUERGEN; EDER ULRICH; WIECHERT RUDOLF
权利人:SCHERING AG
摘要:Bicycloalkane derivatives of the formula ##STR1## WHEREIN N IS 1 OR 2, R 1 is lower alkyl, X is carbonyl or a free or etherified hydroxymethylene, and Y is --S--R 2 , --SO m --R 2 , or ##STR2## wherein m is 1 or 2, R 2 is aryl or aralkyl, R 3 is hydrogen or lower alkyl, R 4 is phenyl optionally substituted with lower alkoxy or benzyloxy, and Z is nitro, lower alkanoyl, lower alkylsulfinyl, or lower alkylsulfonyl, are useful intermediates in the total synthesis of steroids. The compounds are prepared by reacting a corresponding compound lacking the CH 2 Y substituent with formaldehyde and a mercaptan or a sulfinic acid, followed if desired by oxidation and optional salt condensation.

专利号:US-4008253-A
优先权日:1971-12-24
标题 :Bicycloalkanes
发明人：SAUER GERHARD; HAUSER HELMUT; HAFFER GREGOR; RUPPERT JURGEN; EDER ULRICH; WIECHERT RUDOLF
权利人:SCHERING AG
摘要:Bicycloalkane derivatives of the formula ##STR1## WHEREIN N IS 1 OR 2, R 1 is lower alkyl, X is free or ketalized carbonyl or a free, esterified, or etherified hydroxymethylene, and Y is --S--R 2 , --SO m --R 2 , or ##STR2## wherein m is 1 or 2, R 2 is alkyl, aryl, or aralkyl, R 3 is hydrogen or lower alkyl, R 4 is alkoxycarbonyl, or acyl or phenyl optionally substituted with lower alkoxy or benzyloxy- or acyloxy; and Z is nitrile, nitro, lower alkoxycarbonyl, lower alkanoyl, lower alkylsulfinyl, or lower alkylsulfonyl are useful intermediates in the total synthesis of steroids. The compounds are prepared by reacting a corresponding compound lacking the CH 2 Y substituent with formaldehyde and a mercaptan or a sulfinic acid, followed if desired by oxidation and optional salt condensation.