专利号:US-2020079715-A1 优先权日:2018-09-06 标题 :2-position modification for synthesis of resorcinol scaffolding 发明人:DAVIS ROBERT; BLACK JACOB; SMELTZER THOMAS; COLVIN SEAN 权利人:CANOPY HOLDINGS LLC 摘要:A resorcinol with modifications at the 2-position is provided. The reactant resorcinol may have a variety of functional groups at each of the 1, 3, and 5 position such as a hydroxide, a lower alkyl group, a phenyl, a substituted phenyl, a lower alkenyl, or a lower alkynyl sp 2 carbon group (e.g., substituted phenyl, vinyl), sp (e.g., alkyne), hydrogen. The resorcinol is modified at the 2-position with a nucleophile or an electrophile. The resulting resorcinol may serve as a stable intermediate for the synthesis of cannabinoid or cannabinoid derivatives.
专利号:US-11512062-B2 优先权日:2018-10-15 标 题:Process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them 发明人:BEAUREGARD LOUIS-PHILIPPE; BERTRAND MARTIAL; GIGUERE PASCALL; HARDOUIN CHRISTOPHE; SCHIAVI BRUNO 权利人:SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I):
专利号:US-4515952-A 优先权日:1982-03-25 标 题 :Synthesis of 2-pyridylalkylamines substituted on the pyridyl ring by bromine 发明人:ADGER BRIAN M; O'ROURKE DAVID J 权利人:SMITH KLINE FRENCH LAB 摘要:The invention provides a process for preparing 2-pyridylalkylamines, substituted in one of the 3- or 5-positions by bromo and in the other by C 1-4 alkyl, by reacting an appropriate C 1-4 alkyl substituted 2-pyridylalkylamine with an electrophilic brominating agent. Said 2-pyridylalkylamines are useful as intermediates in the synthesis of compounds useful as histamine H 1 -antagonists.
专利号:US-6500954-B1 优先权日:1998-06-22 标 题:Synthesis of 5- or 8-bromoisoquinoline derivatives 发明人:GOULIAEV ALEX HAAHR; HANSEN WILLIAM 权利人:NEUROSEARCH AS 摘要:The present invention is directed to a method of preparing bromoisoquinoline derivatives, in particular 5- or 8-bromoisoquinoline derivatives. Bromoisoquinoline derivatives, and in particular 5-bromoisoquinoline and 5-bromo-8-nitroisoquinoline derivatives, are key intermediates in the synthesis of pharmaceutical compounds.
专利号:US-9000170-B2 优先权日:2012-03-19 标 题:Process for the preparation of tetracarboxynaphthalenediimide compounds disubstituted with heteroaryl groups 发明人:SCHIMPERNA GIULIANA; PELLEGRINO ANDREA; CHIABERGE STEFANO; BIANCHI GABRIELE 权利人:ENI SPA 摘要:A process for the preparation of a tetracarboxynaphthalenediimide compound disubstituted with heteroaryl groups having general formula (I), comprising the reaction of at least one disubstituted N,N′-dialkyl-1,5,8-tetracarboxynaphthalenediimide with at least one heteroaryl compound. Said tetracarboxynaphthalenediimide compound disubstituted with heteroaryl groups can be advantageously used as monomer in the synthesis of semiconductor polymers which can be advantageously used in the construction of organic field effect transistors (OFET) or of organic thin film transistors (OTFT).
专利号:US-2024239924-A1 优先权日:2021-04-30 标题:Synthesis of sulfonyl halide terminated polyethylene 发明人:BROONER RACHEL E M; SENECAL TODD D; KEAN ZACHARY S 权利人:DOW GLOBAL TECHNOLOGIES LLC 摘要:Methods for preparing end-functionalized polyolefin, The methods include polymerizing one or more olefin monomers in the presence of an aluminum chain transfer agent to produce a polymeryl aluminum species; treating the polymeryl aluminum species with sulfur oxide compound at a reactor temperature to form a polymeryl sulfinate; and oxidizing the polymeryl sulfinate; wherein the end-functionalized polyolefin comprises a polymer backbone having at least 30 carbon atoms; and the end-functionalized polyolefin comprises a sulfur containing group,