CAS: 15066-28-1; Pyridine Formate

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CAS号110-86-1 吡啶 | CAS号64-18-6 甲酸

📜吡啶,二氧化碳置于氢气体系中,用 水 用作溶剂,100.0 °C,4.0 Mpa 条件下,反应生成吡啶甲酸盐缓冲液
参考文献:使用简单,可回收和高效的多相催化剂将co 2加氢生成甲酸酯
标题:使用简单,可回收和高效的多相催化剂将co 2加氢生成甲酸酯
摘要:如今,实现工业上co 2转化的最重要的目标之一是开发出具有实用性,选择性和耐用性的,切实可行的催化系统.在此,通过将可商购获得的rucl 3 . X H 2 O首次固定在联吡啶官能化的共价三嗪骨架[bpy-Ctf-Rucl 3 ]上,制备了一种简单的多相ru(III)催化剂.这种新颖的催化剂以前所未有的周转频率(38800 H-1)有效地将co 2加氢成甲酸.)和选择性.此外,该催化剂在连续运行中极佳地保持了效率,并且在短短2.5小时内产生的最大最终甲酸盐浓度约为2.1 M,相对于co 2进料而言,转化率为12%.空气稳定性,易于处理,简单,易于使用的金属前体的使用以及出色的催化性能等明显优势使[bpy-Ctf-Rucl 3 ]成为实现甲酸大规模生产的可能候选者之一酸/甲酸酯通过co 2加氢.
Doi:10.1021/acs.Inorgchem.8B03336

专利信息

专利号:US-9029421-B2
优先权日:2008-06-02
标 题 :Process for the synthesis of arformoterol
发明人：HALDAVANEKAR VAISHALI VAMAN; PRABHU MANGESH; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO
权利人:HALDAVANEKAR VAISHALI VAMAN; PRABHU MANGESH; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; CIPLA LTD
摘要:The present invention provides a process for preparing a compound of formula (VI) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to produce a compound of formula (II) or a salt thereof, wherein there is no isolation of an imine intermediate formed during the reductive amination; (ii) condensing the compound (II) or the acid addition salt thereof with an α-haloketone of formula (III) to produce the compound of formula (IV); (iii) reducing the compound (IV) to a compound of formula (V); and (iv) reducing the compound (V) to the compound of formula (VI), wherein the reduction is carried out in the presence of either (1) a hydrogen donating compound in the presence of a hydrogen transfer catalyst; or (2) ammonium formate using a hydrogenation catalyst, wherein R 1 and R 2 are independently optionally substituted arylalkyl, and Hal is selected from chloro or bromo.

专利号:US-8962839-B2
优先权日:2010-11-19
标题:Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof
发明人：ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN
权利人:ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN; ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO LTD
摘要:The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.

专利号:US-5502183-A
优先权日:1992-01-28
标 题 :Steroid intermediates and processes for their preparation
发明人：ANDREWS DAVID R; SUDHAKAR ANANTHA R
权利人:SCHERING CORP
摘要:PCT No. PCT/US93/00211 Sec. 371 Date Jul. 25, 1994 Sec. 102(e) Date Jul. 25, 1994 PCT Filed Jan. 26, 1993 PCT Pub. No. WO93/15103 PCT Pub. Date Aug. 5, 1993.Novel steroids having a 9 alpha -hydroxy or a 9 alpha -carbonate substituent can be prepared from 9 alpha -hydroxyandrostenedione and can be utilized in the synthesis of commercially valuable corticosteroids such as betamethasone. The 9 alpha -carbonates are prepared by reaction of the corresponding 9 alpha -hydroxy steroid with a sequence of excess base, trialkylsilyl chloride, alkyl haloformate and alkanol or by using excess base, alkyl haloformate and alkoxide. 9 alpha -Carbonate-17-keto compounds can be treated with lithium acetylide and a lithium salt to afford the corresponding 17 alpha -ethynyl-17 beta -hydroxy-9 alpha -carbonate. This compound is then esterified with a novel series of reagents to give the 17-ester which can be reduced the corresponding 17-allene. Oxidation of this allene to the bis-epoxide compound, followed by treatment with an alkali metal salt of a carboxylic acid under phase transfer conditions gives the 17 alpha -hydroxy 21-ester 9 alpha -carbonate. Elimination of the 9 alpha -carbonate group affords the a 17 alpha -hydroxy, 9(11)ene, which in a few subsequent steps can be converted to a variety of commercially important corticosteroids. Novel 9 alpha -carbonate compounds are prepared in the various reaction steps.

专利号:CA-2724882-A1
优先权日:2008-06-02
标 题:Process for the synthesis of arformoterol

专利号:US-9441053-B2
优先权日:2013-07-11
标 题 :Analytical method for detecting sulfated oligosaccharides
发明人：WANG CHUNGYAO; HUANG IMIN; WU CHIAYEN; CHIANG YUNGTE; CHAO HELEN
权利人:SCINOPHARM TAIWAN LTD
摘要:The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including Fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC) coupled with a charged aerosol detector (CAD) or a mass spectrometer (MS). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification. Systems and conditions utilizing such methods are also provided.

专利号:US-2015210629-A1
优先权日:2008-06-02
标题 :Process for the Synthesis of Arformoterol