专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-3759898-A 优先权日:1971-09-14 标 题 :Synthesis of alpha-(carbo(5-indanyloxy)) benzylpenicillin 发明人:NAKANISHI S 权利人:PFIZER 摘要:THE PREPARATION OF A-(CARBO(5-INDANYLOXY))BENZYLPENICILLIN VIA THE ESTERIFICATION OF A-CARBOXYPENICILLIN WITH 5-INDANOL IN THE PRESENCE OF N, N''-DICYCLOHEXYLCARBODIIMIDE IN A REACTION-INERT SOLVENT AT A PH OF 2-8.
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-6225341-B1 优先权日:1995-02-27 标 题:Compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A 权利人:GILEAD SCIENCES INC 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-4033982-A 优先权日:1974-10-16 标 题 :3,4,5-Trithiapolycyclo compounds and derivatives 发明人:HAY ALLAN S 权利人:GEN ELECTRIC 摘要:A process for the preparation of 3,4,5-trithiapolycyclo compounds is described which comprises the reaction of sulfur with bicyclo[2.2.1]hept-2-ene compounds carried out in the presence of (1) a phenol, and (2) a base. The process can be carried out either in the absence or presence of an inert organic solvent. The trithiapolycyclic compounds produced by this process are useful as monomers in the synthesis of polymers which can be employed as additives for lubricants, to produce effective coatings on solid substrates, or to produce fibers and films.
专利号:SU-1766251-A3 优先权日:1988-05-19 标 题:Method for synthesis of s-enantiomeric derivatives of glutaramide or theirs pharmaceutically acceptable salts