马来酸二丁酯置于水,5-甲氧基-1,3,4-三苯基-4,5-二氢-1H-1,2,4-三唑体系中,用 乙二醇二甲醚 用作溶剂,化学反应 2.0H,以94%的收率获得丁二酸二丁酯 参考文献:Transfer Hydrogenation Promoted By N-Heterocyclic Carbene And Water 标题:Transfer Hydrogenation Promoted By N-Heterocyclic Carbene And Water 摘要:N-杂环卡宾(nhcs)促进了各种活化的c=c,C=n和n=n键的氢转移反应,水是质子源. Doi:10.1039/c5Cc05117G
专利号:WO-2024119509-A1 优先权日:2022-12-09 标 题 :Synthesis method for second strand in dnb paired-end sequencing, sequencing method, and related products 发明人:XU CHONGJUN; JIANG LAN; YANG JIN; GONG MEIHUA 权利人:MGI TECH CO LTD 摘要:Provided are a synthesis method for a second strand in DNB paired-end sequencing, a sequencing method, and related products. The synthesis method for the second strand comprises: after DNB is subjected to first-strand sequencing, using a second-strand synthesis primer to synthesize the second strand, wherein the second-strand synthesis primer is a primer capable of being anchored on the surface of a sequencing chip. Using the second-strand synthesis primer that is anchored on the surface of a sequencing vector for the synthesis of the second strand makes the process of synthesizing the second strand relatively more stable. Moreover, the synthesized second-strand template is anchored on the sequencing vector, and subsequent sequencing of the second-strand template strand that is anchored on the sequencing vector can achieve a relatively higher quality of the second-strand sequencing.
专利号:US-2024082118-A1 优先权日:2021-05-19 标 题:Topical compositions and methods of preparing the same 发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION 权利人:LANDA LABS 2012 LTD 摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
专利号:US-2022233673-A1 优先权日:2019-06-04 标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF 发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M 权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND 摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
专利号:US-12221419-B2 优先权日:2022-03-30 标题:Abietanes and methods of making and using the same 发明人:FREDERICH JAMES H; SOLANS MEGAN M 权利人:FLORIDA STATE UNIV RESEARCH FOUNDATION INCORPORATED; UNIV FLORIDA STATE RES FOUND 摘要:In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein is versatile polyene cyclization strategy that exploits conjugated β-ionyl derivatives. Photomediated disruption of the extended Ï€-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C-Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-3835162-A 优先权日:1972-10-25 标 题:Synthesis of citraconic anhydride 发明人:TATE B; BERG R 权利人:PFIZER 摘要:Citraconic anhydride can be prepared in high yield by reacting with an excess of formaldehyde at least one compound selected from the group consisting of succinic anhydride, and di-lower alkyl esters of succinic acid, in the vapor phase at a temperature of about 280-410*C. in the presence of a catalyst selected from the group consisting of thorium sulfate, potassium diacid phosphate, or lithium carbonate on an alundum support, or lithium phosphate. Itaconic acid is conveniently prepared by hydrolyzing the citraconic anhydride to citranconic acid, and then isomerizing the acid to yield itaconic acid.