CAS: 136247-07-9; N-Benzyl-5-Methoxy-1,2,3,4-Tetrahydronaphthalen-2-Amine
该化合物是一种合成有机化合物,其特点是四氢-甲二烯核心在5号位置被甲氧基组取代,在2号位置被乙基苯基胺组取代.这一结构具有作为制药和精细化学合成中间体的潜在效用,特别是在开发生物活性分子方面.甲氧基和苯基胺功能组加强了其反应性,能够有选择地修改有针对性的应用.其明确界定的分子结构确保合成途径的一致性,使其对药用化学和药物发现研究具有价值.该化合物在标准条件下的稳定进一步支持其在实验室环境中的处理和储存.
- 英文名称N-Benzyl-5-Methoxy-1,2,3,4-Tetrahydronaphthalen-2-Amine
- 中文名称5-甲氧基-1,2,3,4-四氢-N-(苯甲基)-2-萘胺
- 其它别名2-Naphthalenamine,1,2,3,4-tetrahydro-5-methoxy-N-(phenylmethyl)-, (?à)-; N-Benzyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)amine
- CAS编号136247-07-9
- 分子式:C18H21NO分子量:267.37
- 产品CID: 564908
- 产品分类医药中间体 → 原料药中间体
物理性质
MSDS等安全信息
上下游产品
CAS号32940-15-1 5-甲氧基-2-萘满酮 | CAS号100-46-9 苄胺 | CAS号575-44-0 1,6-二羟基萘 | CAS号3900-49-0 1,6-二甲氧基萘 | CAS号101403-24-1 (S)-5-甲氧基-1,2,3... | CAS号58349-23-8 (S)-5-甲氧基-1,2,3... | CAS号4018-91-1 5-甲氧基-2-四氢萘胺合成工艺路线路线简述
- 合成目标产物 5-Methoxy-1,2,3,4-Tetrahydro-N-(Phenylmethyl)- 2-Naphthalenamine (Rotigotine) 主要起始原料 5-Methoxy-2-Tetralone And Benzylamine
- (文献来源)合成步骤主要原料 5-Methoxy-2-Tetralone 和 Benzylamine
📜5-甲氧基-2-萘满酮置于platinum(Iv) Oxide 氢气,对甲苯磺酸体系中,用 乙醇,苯 用作溶剂,化学反应 19.5H,反应生成5-甲氧基-1,2,3,4-四氢-N-(苯甲基)-2-萘胺
参考文献:2-Amido-8-Methoxytetralins: A Series Of Nonindolic Melatonin-Like Agents
标题:2-Amido-8-Methoxytetralins: A Series Of Nonindolic Melatonin-Like Agents
摘要:A Series Of Unsubstituted And Methoxy-Substituted 2-Amidotetralins (4A-Q) Was Prepared And Evaluated For Their Ability To Compete For 2-[i-125]Iodomelatonin Binding To Chicken Retinal Membranes And For Their Potency To Inhibit The Calcium-Dependent Release Of [h-3]Dopamine From Rabbit Retina. The Lead Compound,2-Acetamido-8-Methoxytetralin (4J),Showed A Moderate Affinity (K(I) = 46 Nm) And Potency (Ic50 = 1.4 Nm) At The Melatonin Receptor. The Structural Requirements Necessary For Optimal Agonistic Activity At The Melatonin Receptor Are As Follows. First,The Amido Group,Which Should Have A Small,Nonbranched Alkyl Group,Is Essential For Affinity,And Second,The Methoxy Substituent At The 8-Position Of The 2-Amidotetralin Ring Is Essential For Optimal Agonistic Activity At The Melatonin Receptor. We Concluded That This Series Of Unsubstituted And Methoxy-Substituted 2-Amidotetralins Constitutes A Class Of Nonindolic Melatonin-Like Agents That Can Be Used As Pharmacological Tools To Further Characterize Melatonin Receptors And To Elucidate The Mode Of Action Of Melatonin.
Doi:10.1021/jm00072A008
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2907121100-间甲酚
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-4968837-A
优先权日:1989-07-28
标题 :Resolution of racemic mixtures
发明人：MANIMARAN THANIKAVELU; IMPASTATO FRED J
权利人:ETHYL CORP
摘要:Racemic 2-(N-propylamino)-5-methoxytetralin is resolved by treating it with a chiral diaroyltartaric acid in an organic solvent at an elevated temperature to form a salt of the amine and chiral diaroyltartaric acid which is soluble in the solvent at the elevated temperature, cooling to precipitate the salt, isolating it, and converting it to the free amine. The product is useful as an intermediate in the synthesis of optionally-active pharmaceutical, such as N-0437.
专利号:WO-2011146610-A2
优先权日:2010-05-19
标 题 :An enantioselective synthesis of chiral amines for the production of rotigotine
