CAS: 136-77-6; 4-Hexylbenzene-1,3-Diol

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CAS号3144-54-5 2',4'-二羟基苯己酮 | CAS号95-48-7 邻甲酚 | CAS号108-46-3 间苯二酚 | CAS号111-27-3 正己醇 | CAS号34686-76-5 2-Hexenyl bromide | CAS号142-61-0 己酰氯 | CAS号142-62-1 正己酸 | CAS号101002-18-0 3-butoxy-4-hexy... | CAS号143287-10-9 3-butoxy-4-hexy... | CAS号6033-48-3 N-[2-[[4-[2-(4-... | CAS号63411-88-1 1-(5-hexyl-2,4-...

己酸置于盐酸,Zinc(II) Chloride,锌体系中,用 乙醇 用作溶剂,化学反应 6.0H,反应生成4-己基间苯二酚
参考文献:Discovery And Sar Study Of Hydroxyacetophenone Derivatives As Potent,Non-Steroidal Farnesoid X Receptor (Fxr) Antagonists
标题:Discovery And Sar Study Of Hydroxyacetophenone Derivatives As Potent,Non-Steroidal Farnesoid X Receptor (Fxr) Antagonists
摘要:Compound 1 (Ic50 = 35.2 +/-7.2 Mu M),A Moderate Fxr Antagonist Was Discovered Via High-Throughput Screening. Structure-Activity Relationship Studies Indicated That The Shape And The Lipophilicity Of The Substituents Of The Aromatic Ring Affect The Activity Dramatically,Increasing The Shape And The Lipophilicity Of The Substituents Of The Aromatic Ring Enhances The Potency Of Fxr Antagonists. Especially,When The Oh At C2 Position Of The Aromatic Ring Was Replaced By The Obn Substituent (Analog 2B),Its Activity Could Be Improved To Ic50 = 1.1 +/-0.1 Mu M. Besides,The Length Of The Linker And The Tetrazole Structure Are Essential For Retaining The Activity. (C) 2014 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2014.01.032

专利信息

专利号:US-4895922-A
优先权日:1988-05-05
标 题 :Low temperature synthesis of polyesteramides
发明人：OGATA NAOYA
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention disclosed a process for the synthesis of polyesteramides. By utilizing the phosphorus containing catalyst systems of the present invention, such polyesteramides can be synthesized at relatively low temperatures. The present invention specifically discloses a process for the synthesis of a polyesteramide which comprises polymerizing at least one diamine, at least one diol, and at least one dicarboxylic acid in the presence of (1) at least one acid acceptor; (2) at least one halogenated organic compound; and (3) at least one phosphorus containing compound selected from the group consisting of (a) triphenylphosphine, (b) triphenylphosphine oxide, (c) triphenylphosphine sulfide, (d) polymeric agents having pendant diphenylphosphine groups, (e) silicon-phosphorus compositions which contain at least one divalent oxygen atom which is bonded directly to a tetravalent silicon atom and a trivalent or pentavalent phosphorus atom; (f) compounds with the structural formula (C 6 H 5 ) 3 P=N-R, wherein R is a hydrogen atom or an alkyl group containing from 1 to 10 carbon atoms; and (g) compounds with the structural formula (C 6 H 5 )PR 1 R 2 wherein R 1 and R 2 can be the same or different, wherein R 1 is selected from the group consisting of alkyl groups containing from 1 to 10 carbon atoms and phenyl groups, and wherein R 2 is an alkyl group containing from 1 to 10 carbon atoms.

专利号:US-4923839-A
优先权日:1987-02-05
标题:Low temperature synthesis of condensation polymers
发明人：OGATA NAOYA
权利人:GOODYEAR TIRE & RUBBER
摘要:Condensation polymers of high molecular weight, such as polyesters, polyureas, and polyamides, are usually prepared at temperatures of 200° C. or greater. However, by utilizing the catalyst systems of the present invention, condensation polymers can be synthesized at much lower temperatures. The polycondensation catalyst systems of the present invention are particularly useful for synthesizing aliphatic polyesters, such as polyethylene terephthalate, from dicarboxylic acids and aliphatic glycols. The present invention more specifically discloses a process for the synthesis of an aliphatic polyester comprising polymerizing at least one dicarboxylic acid with at least one aliphatic glycol in the presence of (1) at least one phosphorus containing compound which contains at least one trivalent or pentavalent phosphorus atom which is bonded directly to at least one phenyl group, (2) an acid acceptor, and (3) at least one halogenated organic compound. It is preferred to utilize a polymeric agent having bound acid acceptor groups as the acid acceptor in the process of the present invention.

专利号:US-4843053-A
优先权日:1987-02-05
标 题 :Low temperature synthesis of condensation polymers
发明人：OGATA NAOYA
权利人:GOODYEAR TIRE & RUBBER
摘要:Condensation polymers of high molecular weight, such as polyesters, polyureas, and polyamides, are usually prepared at temperatures of 200° C. or greater. However, by utilizing the catalyst systems of the present invention, condensation polymers can be synthesized at much lower temperatures. The polycondensation catalyst systems of the present invention are particularly useful for synthesizing aliphatic polyesters, such as polyethylene terephthalate, from dicarboxylic acids and aliphatic glycols. The present invention more specifically discloses a process for the synthesis of an aliphatic polyester comprising polymerizing at least one dicarboxylic acid with at least one aliphatic glycol in the presence of (1) at least one phosphorus containing compound which contains at least one trivalent or pentavalent phosphorus atom which is bonded directly to at least one phenyl group, (2) an acid acceptor, and (3) at least one halogenated organic compound. It is preferred to utilize a polymeric agent having bound acid acceptor groups as the acid acceptor in the process of the present invention.

专利号:US-4996178-A
优先权日:1987-02-05
标题 :Low temperature synthesis of condensation polymers
发明人：OGATA NAOYA
权利人:GOODYEAR TIRE & RUBBER
摘要:Condensation polymers of high molecular weight, such as polyesters, polyureas, and polyamides, are usually prepared at temperatures of 200° C. or greater. However, by utilizing the catalyst systems of the present invention, condensation polymers can be synthesized at much lower temperatures. The polycondensation catalyst systems of the present invention are particularly useful for synthesizing aliphatic polyesters, such as polyethylene terephthalate, from dicarboxylic acids and aliphatic glycols. The present invention more specifically discloses a process for the synthesis of an aliphatic polyester comprising polymerizing at least one dicarboxylic acid with at least one aliphatic glycol in the presence of (1) at least one phosphorus containing compound which contains at least one trivalent or pentavalent phosphorus atom which is bonded directly to at least one phenyl group, (2) an acid acceptor, and (3) at least one halogenated organic compound. It is preferred to utilize a polymeric agent having bound acid acceptor groups as the acid acceptor in the process of the present invention.

专利号:US-2006129002-A1
优先权日:2004-12-15
标 题:Process for the synthesis of alkylresorcinols
发明人：WASSMANN-WILKEN SUZANNE; SCHMIDT HANS-JURGEN; WILKEN JORG; KANSCHIK-CONRADSEN ANDREAS
权利人:HONEYWELL INT INC
摘要:The invention provides a process for the production of 4-(C 2 -C 16 )alkylresorcinol. 4-(C 2 -C 16 )alkylresorcinol is produced by reacting resorcinol with a (C 2 -C 16 )alkyloic acid in the presence of a zinc chloride catalyst to produce an intermediate comprising a 4-(C 2 -C 16 )acylresorcinol and zinc ions. Then the intermediate is adjusted such that the zinc ion content is from about 0.1 to about 150 parts per million based on the weight of the intermediate to form an adjusted intermediate. Then the produced 4-(C 2 -C 16 )acylresorcinol is hydrogenated in the presence of the zinc ions and a base metal hydrogenation catalyst to produce a crude product comprising 4-(C 2 -C 16 )alkylresorcinol, which may thereafter be isolated.

专利号:US-4804730-A
优先权日:1987-02-05
标 题 :Process for producing an aliphatic polyester by polymerizing dicarboxylic acid and glycol in the presence of phosphorus or silicon-phosphorus compound acid acceptor and halogenated organic compound
发明人：OGATA NAOYA
权利人:GOODYEAR TIRE & RUBBER
摘要:Condensation polymers of high molecular weight, such as polyesters, polyureas, and polyamides, are usually prepared at temperatures of 200° C. or greater. However, by utilizing the catalyst systems of the present invention, condensation polymers can be synthesized at much lower temperatures. The polycondensation catalyst systems of the present invention are particularly useful for synthesizing aliphatic polyesters, such as polyethylene terephthalate, from dicarboxylic acids and aliphatic glycols. The present invention more specifically discloses a process for the synthesis of an aliphatic polyester comprising polymerizing at least one dicarboxylic acid with at least one aliphatic glycol in the presence of (1) at least one phosphorus containing compound which contains at least one trivalent or pentavalent phosphorus atom which is bonded directly to at least one phenyl group, (2) an acid acceptor, and (3) at least one halogenated oganic compound. It is preferred to utilize a polymeric agent having bound acid acceptor groups as the acid acceptor in the process of the present invention.