CAS: 13122-90-2; Boc-Phe-Phe-Oh

该化合物是一种合成化合物,属于氨酸衍生物类别,该物质具有一种复杂的结构,其特点是存在两种苯丙氨残留物,这些残留物是因其疏水特性而闻名的芳香氨酸酸.该化合物包括二甲基乙基碳基保护组,该组物经常用于双甲基乙基碳基化合物合成合成合成,以保护化学反应过程中的氨基化合物.这一保护组物加强了该化合物在各种溶剂中的稳定性和溶性.该碳基化合物的存在表明其潜在的再活动性,使其在进一步的合成应用中有用.该化合物通常用于有关蛋白化合物结构和功能的研究中,其独特的结构特征有助于其在生物化学应用中的作用,包括药物开发和酶相互作用研究.

结构式图片

相似化合物

125511-90-2 2577-40-4 84889-09-8

物理性质

MSDS等安全信息

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合成工艺路线路线简述

  • 合成目标产物 Boc-Phe-Phe-Oh 主要起始原料 Methyl L-Phenylalaninate Hydrochloride
  • (文献来源)合成步骤主要原料 Methyl L-Phenylalaninate Hydrochloride
📜Boc-L-苯丙氨酸琥珀酰亚胺酯置于lithium Hydroxide,三乙胺体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 5.0H,反应生成Boc-L-苯丙氨酰-苯丙氨酸
参考文献:Synthesis And Characterization Of Peptide−cationic Steroid Antibiotic Conjugates
标题:Synthesis And Characterization Of Peptide−cationic Steroid Antibiotic Conjugates
摘要:New Cationic Steroid Antibiotics Have Been Prepared By Conjugating Tripeptides To A Triamino Analogue Of Cholic Acid. These Compounds Were Synthesized On A Solid Phase In An Indexed Library That Was Screened For Antibacterial Activity Against Gram-Negative And Gram-Positive Bacteria. Selected Compounds Were Synthesized On A Larger Scale,And Minimum Inhibition Concentrations Were Measured. These Results Correlated Very Well With The Screening Of The Indexed Library Of Antibiotics. The Most Active Antibiotics Demonstrate A Marked Improvement Over A Related And Well Characterized Cationic Steroid Antibiotic.
Doi:10.1021/ol048845T

海关参考信息

专利信息


专利号:US-3842067-A
优先权日:1973-07-27
标 题:Synthesis of(des-asn5)-srif and intermediates
发明人：SARANTAKIS D
权利人:AMERICAN HOME PROD
摘要:AND THE NON-TOXIC ACID ADDITION SALTS THEREOF, SAID AMINO ACID RESIDUES HAVING AN ASYMMETRIC A-CARBON ATOM BEING OF THE L-FORM. H-ALA-GLY-CYS-LYS-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-ALA-GLY-CYS-LYS-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH, 1. A COMPOUND SELECTED FROM THOSE OF THE FORMULA:

专利号:CN-113773295-B
优先权日:2021-09-26
标 题 :Synthesis method of monosubstituted dihydro chromone and application of monosubstituted dihydro chromone in treatment of pulmonary inflammation such as COPD (chronic disease)

专利号:CN-113773295-A
优先权日:2021-09-26
标 题 :Synthesis method of mono-substituted dihydrochromone and application of mono-substituted dihydrochromone in treating lung inflammation such as COPD (chronic obstructive pulmonary disease)

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合成参考文献

合成方法参考DOI号:10.1021/acs.jmedchem.0c01935
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