CAS: 13122-90-2; Boc-Phe-Phe-Oh

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125511-90-2 2577-40-4 84889-09-8

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Boc-L-苯丙氨酸琥珀酰亚胺酯置于lithium Hydroxide,三乙胺体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 5.0H,反应生成Boc-L-苯丙氨酰-苯丙氨酸
参考文献:Synthesis And Characterization Of Peptide−cationic Steroid Antibiotic Conjugates
标题:Synthesis And Characterization Of Peptide−cationic Steroid Antibiotic Conjugates
摘要:New Cationic Steroid Antibiotics Have Been Prepared By Conjugating Tripeptides To A Triamino Analogue Of Cholic Acid. These Compounds Were Synthesized On A Solid Phase In An Indexed Library That Was Screened For Antibacterial Activity Against Gram-Negative And Gram-Positive Bacteria. Selected Compounds Were Synthesized On A Larger Scale,And Minimum Inhibition Concentrations Were Measured. These Results Correlated Very Well With The Screening Of The Indexed Library Of Antibiotics. The Most Active Antibiotics Demonstrate A Marked Improvement Over A Related And Well Characterized Cationic Steroid Antibiotic.
Doi:10.1021/ol048845T

专利信息

专利号:US-3842067-A
优先权日:1973-07-27
标 题:Synthesis of(des-asn5)-srif and intermediates
发明人：SARANTAKIS D
权利人:AMERICAN HOME PROD
摘要:AND THE NON-TOXIC ACID ADDITION SALTS THEREOF, SAID AMINO ACID RESIDUES HAVING AN ASYMMETRIC A-CARBON ATOM BEING OF THE L-FORM. H-ALA-GLY-CYS-LYS-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-ALA-GLY-CYS-LYS-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH, 1. A COMPOUND SELECTED FROM THOSE OF THE FORMULA:

专利号:CN-113773295-B
优先权日:2021-09-26
标 题 :Synthesis method of monosubstituted dihydro chromone and application of monosubstituted dihydro chromone in treatment of pulmonary inflammation such as COPD (chronic disease)

专利号:CN-113773295-A
优先权日:2021-09-26
标 题 :Synthesis method of mono-substituted dihydrochromone and application of mono-substituted dihydrochromone in treating lung inflammation such as COPD (chronic obstructive pulmonary disease)