CAS: 1234015-52-1; 5-((5-(2-(3-Aminopropoxy)-6-Methoxyphenyl)-1H-Pyrazol-3-yl)Amino)Pyrazine-2-Carbonitrile

上下游产品

Tert-Butyl (3-(2-(3-((5-Cyanopyrazin-2-yl)Amino)-1H-Pyrazol-5-yl)-3-Methoxyphenoxy)Propyl)Carbamate 1234015-66-7
5-((5-(2-Methoxy-6-((4-Methoxybenzyl)Oxy)Phenyl)-1H-Pyrazol-3-yl)Amino)Pyrazine-2-Carbonitrile 1234015-68-9
Tert-Butyl 3-(2-(3-(5-Bromopyrazin-2-Ylamino)-1H-Pyrazol-5-yl)-3-Methoxyphenoxy)Propylcarbamate 1234015-65-6
2-(3-(5-Bromopyrazin-2-Ylamino)-1H-Pyrazol-5-yl)-3-Methoxyphenol 1234015-64-5
5-Bromo-N-(5-(2-Methoxy-6-(4-Methoxybenzyloxy)Phenyl)-1H-Pyrazol-3-yl)Pyrazin-2-Amine 1234015-63-4

📜1-(2-甲氧基-6-((4-甲氧基苄基)氧基)苯基)-3,3-双(甲硫基)丙-2-烯-1-酮置于四(三苯基膦)钯 盐酸,正丁基锂,偶氮二甲酸二异丙酯,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,正己烷,二氯甲烷,水,乙酸乙酯,N,N-二甲基甲酰胺 用作溶剂,化学反应 32.83H,反应生成5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈
参考文献:Compounds Useful For Inhibiting Chk1
标题:Compounds Useful For Inhibiting Chk1
摘要:本发明提供了一种氨基吡唑化合物,或其药用可接受的盐或该盐的溶剂合物,该化合物抑制chk1,在癌症治疗中具有用处.

专利信息

专利号:WO-2023226658-A1
优先权日:2022-05-25
标题:Nitrogen-containing five-membered heterocyclic derivatives as checkpoint kinase 1 inhibitor and uses thereof
发明人：LIU HANLAN; MA JINGJING; HUANG YUNG-JEN; CAI ZHANG; WANG XIAOHUI; YAN ZHIYU; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; RUAN JUXIN
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to nitrogen-containing five-membered heterocyclic derivatives usefulness in treatment of conditions associated with Checkpoint kinase (CHK), particularly more specifically CHK-1 enzymes. Methods of use, compositions, and method of synthesis are also disclosed.

专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

专利号:WO-2022162606-A1
优先权日:2021-01-30
标 题:Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：YAN ZHIYU; WANG XIAOHUI; LIU HANLAN; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; PENDHARKAR DHANANJAY; JADHAVAR PRADEEP S; SAEED UZMA; KUMAR VIVEK
权利人:SPEROGENIX THERAPEUTICS LTD; INTEGRAL BIOSCIENCES PRIVATE LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed. Formula (J)