CAS: 123-70-6; N1,N3-Dimethyl-N1-(3-(Methylamino)Propyl)Propane-1,3-Diamine

该化合物是一种有机化合物,其特征为有矿功能组;该物质具有两种丙基链的中甲基胺,其中各含有一种基质和潜在反应力;该物质一般是一种无色的黄色液体,具有一种独特的矿泉味;该化合物在水和各种有机溶剂中溶解,可使其适应不同的用途;该化合物的结构允许氢结合,这种结合能够影响其物理特性,例如沸点和粘度;Bis(3-(甲基氨)丙基)甲基胺经常用于聚合物,表面活性剂和有机化学中的再剂;由于存在多种矿类,它可以作为协调化学的离子,并可能展示生物活动,因此需要谨慎处理潜在的毒性.

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6711-48-4 19475-28-6 19475-35-5

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N-methyl-3-methyl-3-[(methylamino)-3-oxopropyl]aminopropanamide 3-methyl-amino)-propyl]-methyl-amino}-propyl)-methyl-carbamoyl]-2-isopropyl-phenyl}-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carboxylic acid methyl ester1-{4-[(3-{[3-(DOTA(tBu)3-methyl-amino)-propyl]-methyl-amino}-propyl)-methyl-carbamoyl]-2-isopropyl-phenyl}-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carboxylic acid methyl ester 3-methyl-amino)-propyl]-methyl-amino}-propyl)-methyl-carbamoyl]-2-isopropyl-phenyl}-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carboxylic acid1-{4-[(3-{[3-(DOTA(tBu)3-methyl-amino)-propyl]-methyl-amino}-propyl)-methyl-carbamoyl]-2-isopropyl-phenyl}-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carboxylic acid 3-methylamino)propyl]methylamino}propyl)methylcarbamoyl]-2-isopropylphenyl}-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino}adamantane-2-carboxylic acid2-{[1-{4-[(3-{[3-(DOTA(tBu)3-methylamino)propyl]methylamino}propyl)methylcarbamoyl]-2-isopropylphenyl}-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino}adamantane-2-carboxylic acid

合成工艺路线路线简述

    N-Methyl-3-Methyl-3-[(Methylamino)-3-Oxopropyl]Aminopropanamide置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应 12.0H,以49%的收率获得n,N',N''-三甲基二丙撑三胺
    参考文献:A New Stepwise Synthesis Of A Family Of Propylamines Derived From Diatom Silaffins And Their Activity In Silicification
    标题:A New Stepwise Synthesis Of A Family Of Propylamines Derived From Diatom Silaffins And Their Activity In Silicification
    摘要:介绍了一种逐步合成含有硅藻生物提取物中发现的 N-甲基丙胺片段的丙胺的新方法,并描述了它们在硅酸缩合中的活性.
    Doi:10.1039/b515967A

    海关参考信息

    专利信息


    专利号:US-2013102730-A1
    优先权日:2010-04-02
    标 题:Polyamine-containing polymers and methods of synthesis and use
    发明人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN
    权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES
    摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).

    专利号:US-2024360105-A1
    优先权日:2021-08-04
    标 题 :Process for polyamide synthesis
    发明人:ZHANG CHENGZHI
    权利人:DESIGN THERAPEUTICS INC
    摘要:The disclosure relates to synthetic methods for producing polyamides, for example pyrrole and imidazole containing polyamides of Formula (I) or (II), or a pharmaceutically acceptable salts thereof. These polyamides bind genes having expanded oligonucleotide repeat sequences, which thereby modulates transcription. The disclosure further provides methods of modulation of the transcription of such DNA, and the use of polyamides as therapeutic agents to treat diseases associated with such DNA.

    专利号:US-6583280-B1
    优先权日:2000-05-26
    标 题 :Polyamine analogues having antiproliferative activity
    发明人:SAAB-ISHMAIL NADA H
    摘要:Novel compounds are chiral compounds which are conformationally restricted polyamine analogues for use in imaging and for therapeutic use in treatment of tumors. These analogues diminish the ability to aggregate DNA seen in the parent polyamines. The invention provides for synthesis of a library of analogues with fine structural modifications which retain restriction and conservation of the molecular weight of the parent polyamines.

    专利号:US-2013102079-A1
    优先权日:2010-04-02
    标 题 :Polyamine-containing polymers and methods of synthesis and use

    专利号:WO-2011120156-A1
    优先权日:2010-04-02
    标 题 :Polyamine-containing polymers and methods of synthesis and use

    专利号:CA-2795084-A1
    优先权日:2010-04-02
    标 题:Polyamine-containing polymers and methods of synthesis and use
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    主要参考文献

    [参考文献]: D F Brown, Et Al. Gold Thioglucose, Mimpa And Lesions Of The Ventromedial Hypothalamus. J Neuropathol Exp Neurol. 1984 Jul;43(4):455-7.
    [参考文献]: D F Brown, Et Al. The Effect Of Alloxan-Induced Diabetes On Triamine Lesions In The Ventromedial Hypothalamus. Physiol Behav. 1991 Jan;49(1):41-6.
    [参考文献]: D Nochlin, Et Al. Ultrastructure Of Hypothalamic And Medullary Lesions Caused By An Aliphatic Triamine. J Neuropathol Exp Neurol. 1982 Mar;41(2):233-40.
    [参考文献]: J C Lyons, Et Al. Gaucher'S Disease And Glioblastoma Multiforme In Two Siblings: A Clinicopathologic Study. J Neuropathol Exp Neurol. 1982 Jan;41(1):45-53.
    [参考文献]: S Levine, Et Al. Localization Of Toxic Encephalopathies Near Lesions Of Experimental Allergic Encephalomyelitis. Am J Pathol. 1982 May;107(2):135-41.

    合成参考文献


    参考文献:10.1097/00005072-198201000-00005
    摘要:Lyons JC, Scheithauer BW, Ginsburg WW. Gaucher's disease and glioblastoma multiforme in two siblings: a clinicopathologic study. J Neuropathol Exp Neurol. 1982 Jan;41(1):45–53. doi: 10.1097/00005072-198201000-00005.
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