专利号:US-5369017-A 优先权日:1994-02-04 标题 :Process for solid phase glycopeptide synthesis 发明人:WONG CHI-HUEY; SCHUSTER MATTHIAS 权利人:SCRIPPS RESEARCH INST 摘要:A process for the synthesis of a glycopeptide using a solid phase matrix is disclosed. The matrix is compatible with aqueous and organic solvents and is comprised of a silica-based solid support to which is linked a two-part spacer group having a chain length of about 12 to about 40 methylene groups. The first part of the spacer is covalently bonded to the silica-based support and has a length of about 3 to about 10 methylene groups. The second spacer part is covalently bonded to the first part of the spacer and comprises the distal end of the two part spacer. The second part is soluble as a free molecule in each of water, dimethylformamide and dichloromethane and has a terminal amine or hydroxyl group to which the C-terminal residue of the peptide portion of the glycopeptide chain is bonded. The chain of atoms connecting the desired glycopeptide to the solid phase matrix also includes a moiety having a selectively severable bond which on cleavage of that bond separates the matrix from whatever else is bonded to that moiety.
专利号:CN-102372690-A 优先权日:2010-08-20 标 题:Intermediate for the synthesis of imatinib and its application in the synthesis of imatinib
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:US-4136033-A 优先权日:1969-11-07 标 题:6-hydroxypyridone-2 compounds having a cationic group in the 3-position 发明人:STEINEMANN WILLY 权利人:SANDOZ LTD 摘要:Compounds of the formula ##STR1## wherein K.sup.⊕ is a cationic group, preferably heterocyclic, n R is hydrogen or an organic radical, preferably alkyl, phenyl or acyl, n R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, substituted heterocyclyl, amino or substituted amino, and n A.sup.⊖ is an anion, n Are useful as intermediates in the synthesis of azo dyes of the formula ##STR2## wherein D is an aromatic carbocyclic or heterocyclic diazo component radical, and n K.sup.⊕, r, r 1 and A.sup.⊖ are as defined above.
专利号:US-4243606-A 优先权日:1976-10-12 标 题 :N-Substituted anilines 发明人:BOURDAUDUCQ PAUL M C; BROUARD CLAUDE M H E; MOEREL CLAUDE L E; STIOT JEAN-PIERRE H 权利人:UGINE KUHLMANN 摘要:The present invention relates to new N-substituted anilines which correspond to the general formula: ##STR1## in which R 1 represents an alkyl radical or substituted alkyl radical, R 2 represents a hydrogen atom, an alkyl radical or substituted alkyl radical, R 3 represents a cyano, carbamoyl, carboxy or carbalkoxy radical and R 4 represents a hydrogen or halogen atom or an alkyl or alkoxy radical. These compounds are valuable intermediates for the preparation of coloring materials, especially as coupling compounds for the synthesis of azo dyes.
专利号:CN-112724055-A 优先权日:2021-01-13 标 题:A method for the synthesis of aromatic monofluoromethylthio compounds by one-pot method
摘要:Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku, Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972, -(133), 1972 摘要:F. Kieffer and P. Rumpf. Compt. Rend. 230, 1874 (1950). 摘要:Schafer, E.W. 1972. The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicology and Applied Pharmacology. 21:315-330. 摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf