CAS: 117-99-7; (2-Hydroxyphenyl)(Phenyl)Methanone

该化合物其结构特征为有机化合物,具有氢氧基(-OH)和苯并苯酮的特性.该化合物通常是白色到光黄色晶体结晶,其熔点因纯度不同而不同.在乙醇和丙酮等有机溶剂中可溶解,但在水中可溶性有限.2-Hydroxybenzophenone主要用作太阳检查和化妆品中的紫外线过滤器,提供防护,防止有害的紫外线辐射.此外,该化合物在塑料和涂层中可用作光稳定剂,增强其耐紫外线降解的耐久性.该化合物在紫外线中表现出良好的吸收作用,使其对预期应用有效.但必须指出,人们担心其潜在的内分泌干扰效应和环境影响,导致各区域的监管审查.

结构式图片

相似化合物

835-11-0 3098-18-8 1470-57-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号119-61-9 二苯甲酮 | CAS号90-02-8 水杨醛 | CAS号98-80-6 苯硼酸 | CAS号89-95-2 邻甲基苄醇 | CAS号71-43-2 苯 | CAS号5663-67-2 Benzaldehyde,2-... | CAS号93-99-2 苯甲酸苯酯 | CAS号93-97-0 苯甲酸酐 | CAS号108-95-2 苯酚 | CAS号55082-33-2 5-溴-2-羟基二苯甲酮 | CAS号18803-19-5 (2-hydroxy-5-ni... | CAS号182499-95-2 (2-hydroxy-3-ni... | CAS号221458-86-2 phenyl-[2-(2-ph... | CAS号1801-99-6 phenyl-(2-sulfa... | CAS号93-99-2 苯甲酸苯酯 | CAS号16513-74-9 [4-(Benzoyloxy)... | CAS号2589-81-3 2,4-dibenzoylphenol | CAS号1137-42-4 4-羟基二苯甲酮 | CAS号33719-60-7 (2-benzoylpheny...

合成工艺路线路线简述

  • 合成目标产物 2-Hydroxybenzophenone 主要起始原料 Bromobenzene And Salicylaldehyde
  • (文献来源)合成步骤主要原料 Bromobenzene 和 Salicylaldehyde
苯甲酸苯酯置于aluminum (III) Chloride体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,以99%的收率获得2-羟基二苯甲酮
参考文献:Preparation Of Benzoyloxy Benzophenone Derivatives And Their Inhibitory Effects Of Icam-1 Expression
标题:Preparation Of Benzoyloxy Benzophenone Derivatives And Their Inhibitory Effects Of Icam-1 Expression
摘要:苯甲酰氧基二苯甲酮衍生物通过三个步骤合成,包括dcc偶联,Fries重排和酯化反应,总产率为24-89%.在合成的12种二苯甲酮类似物1A-1L中,化合物1B在苯环上具有三个氯原子,显示出对icam-1表达的最大抑制效果,而没有任何取代基的化合物1A则没有表现出抑制活性.这项研究表明,苯甲酰氧基二苯甲酮衍生物1B可能通过抑制ifn-${\gamma}$-诱导的icam-1表达来发挥其抗炎活性.
Doi:10.5012/bkcs.2012.33.6.1939

海关参考信息

专利信息


专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人:KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:WO-2024260915-A1
优先权日:2023-06-19
标题:Dynamic covalent chemistry of spiropyrans for synthesis of photoswitchable photoinitiators and uses thereof
发明人:GARMSHAUSEN YVES
权利人:XOLO GMBH
摘要:The present invention relates to spiropyrans and process for the manufacture of them. In particular, a method is provided to exchange the indole and salicylaldehyde part of a spiropyran in a reversible reaction. The method is used for the synthesis of dual color photoinitiators with specific substituents and substitution patterns, which result in improved dual color volumetric printing (xolography). Furthermore, a process for locally polymerizing a starting material by dual color photopolymerization is disclosed.

专利号:EP-4428168-A1
优先权日:2023-03-08
标 题 :Polyurethane/oligomeric urethane synthesis method by radiation
发明人:AKBULUT HÜSEYIN; ÇEL KBA SENA; ENADA SEHER; U AKLI MÜGE; DEM RBAY DUYGU
权利人:CHT TURKEY KIMYA SANAYI VE TICARET A S
摘要:In particular, the invention relates to the synthesis of radiation-curable polyurethane/oligomeric urethane dispersions of anionic and cationic characters, containing neutralization techniques characterized by the selection of counter ions as monomers and/or agents which can be polymers acting as promoters under radiation, to a radiation polyurethane/oligomeric urethane synthesis method that enables the creation of radiation curable binder systems without using cosolvents, surfactants, emulsifiers, defoamers, stabilizers and additives, wherein all components of the radiation-curable binder systems can be polymerized.

专利号:US-2022089618-A1
优先权日:2019-01-29
标题:Solid-State Synthesis Of Precursors Of Metal-Organic Frameworks
发明人:MAJANO GERARDO J; FALKOWSKI JOSEPH M
权利人:EXXONMOBIL RES & ENG CO
摘要:Metal-organic frameworks (MOFs) are highly porous entities comprising a multidentate ligand coordinated to multiple metal atoms, typically as a coordination polymer. MOFs are usually produced from a solvent in powder form under hydrothermal or solvothermal synthesis conditions. Alternately, powder-form precursors of MOFs may be formed by milling or mulling a substantially solid mixture of a metal salt and a multidentate organic ligand, optionally in the presence of a small amount of a solvent. The powder-form precursors may then undergo heating, typically in the absence of applied shear, to produce the corresponding MOF. Mulling may be differentiated from milling at least in that mulling applies to the substantially solid mixture at a non-constant pressure and milling applies a constant pressure while forming the powder-form precursor. In some cases, mulling may promote more effective formation of the powder-form precursor compared to milling.

专利号:US-2009318592-A1
优先权日:2005-10-11
标 题 :Process for the Synthesis of Amine Ethers
发明人:FREY MARKUS; BROENNIMANN VALERIE
权利人:CIBA GEIGY CORP
摘要:The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.

专利号:US-2007191516-A1
优先权日:2004-03-15
标题 :Process for the synthesis of amine ethers
发明人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
权利人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
摘要:A process for the preparation of a sterically hindered amine ether which comprises reacting a corresponding sterically hindered aminoxide with a C 5 -C 18 alk-1-ene in the presence of an organic hydroperoxide and optionally hydrogenating the resulting product as well as the product mixtures obtained therewith and their use as stabilizers and flame retardants.
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主要参考文献

[参考文献]: Marina G Pintado-Herrera, Et Al. Atmospheric Pressure Gas Chromatography-Time-Of-Flight-Mass Spectrometry (Apgc-Tof-Ms) For The Determination Of Regulated And Emerging Contaminants In Aqueous Samples After Stir Bar Sorptive Extraction (Sbse). Anal Chim Acta. 2014 Dec 3:851:1-13.
[参考文献]: Marina G Pintado-Herrera, Et Al. In-Cell Clean-Up Pressurized Liquid Extraction And Gas Chromatography-Tandem Mass Spectrometry Determination Of Hydrophobic Persistent And Emerging Organic Pollutants In Coastal Sediments. J Chromatogr A. 2016 Jan 15:1429:107-18.

合成参考文献


摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 204.
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 110.
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 114.
摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 154.
摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 172.
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