CAS: 111128-12-2; 2-(4-(Bromomethyl)Phenyl)Propanoic Acid

上下游产品

CAS号492-37-5 2-苯基丙酸 | CAS号57-09-0 十六烷基三甲基溴化铵

2-苯基丙酸置于聚合甲醛,硫酸,氢溴酸,Tin(II) Bromide,Sodium Hydroxide,三氯氧磷体系中,用 甲基环己烷 用作溶剂,化学反应 2.0H,反应生成2-(4-溴甲基苯基)丙酸
参考文献:一种对溴甲基异苯丙酸的合成方法
标题:一种对溴甲基异苯丙酸的合成方法
摘要:本发明提供了一种对溴甲基异苯丙酸的合成方法,涉及有机合成技术领域.本发明合成方法包括异苯丙酸酯合成,Vilsmeier试剂制备,对醛基异苯丙酸酯合成,对羟甲基异苯丙酸合成,对溴甲基异苯丙酸合成以及分离纯化等步骤.本发明所述方法的最终对位选择性可达90‑97%,且三废产率大大减少,更加适合国家所倡导经济,环保良性产业发展方向.

专利信息

专利号:US-9115172-B2
优先权日:2007-01-11
标 题 :Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
发明人：D SOUZA CHRISTOPHER A; MCBRIDE WILLIAM J; GOLDENBERG DAVID M
权利人:IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of 18 F- or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may then be directly or indirectly attached to the targeting molecule. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the bifunctional chelating agent bound to 18 F- or 19 F-metal complex may be conjugated to the molecule to be labeled at a reduced temperature, e.g. room temperature.

专利号:US-2016045626-A1
优先权日:2007-01-11
标题 :Methods and Compositions for Improved Labeling of Targeting Peptides
发明人：MCBRIDE WILLIAM J; GOLDENBERG DAVID M
权利人:IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of labeled targeting peptides, such as octreotide, octreotate, or other somatostatin analogs or derivatives. The targeting peptide may be labeled with a therapeutic or diagnostic isotope, such as 61 Cu, 62 Cu, 64 Cu, 67 Cu, 18 F, 19 F, 66 Ga, 67 Ga, 68 Ga, 72 Ga, 111 In, 177 Lu, 44 Sc, 47 Sc, 86 Y, 88 Y, 90 Y, 45 Ti or 89 Zr, preferably 18 F or 19 F. More preferably, the targeting peptide is NOTA-octreotate, NOTA-MPAA-octreotate, pyridine-NOTA-octreotate or triazole-NOTA-octreotate. The labeled targeting peptides may be used for detection, diagnosis, imaging and/or treatment of sst 2 + tumors, such as neuroendocrine tumors.

专利号:US-9028800-B2
优先权日:2007-01-11
标 题 :Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
发明人：D SOUZA CHRISTOPHER A; MCBRIDE WILLIAM J; GOLDENBERG DAVID M
权利人:IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of 18 F or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.

专利号:CN-108084024-A
优先权日:2017-12-08
标题 :Main impurities in the synthesis of loxoprofen sodium intermediate 2-(4-bromomethylphenyl)propionate and its preparation and separation method

专利号:KR-102717162-B1
优先权日:2022-03-18
标题:Synthesis method of pelubiprofen intermediate and pelubiprofen

专利号:CN-113929577-B
优先权日:2021-11-05
标 题 :A kind of synthesis method of 2-(4-methylphenyl)-propionate