CAS: 105812-81-5; (3S,4R)-4-(4-Fluorophenyl)-3-Hydroxymethyl-1-Methylpiperidine

上下游产品

CAS号335158-58-2 (-)-(3S,4R)-4-(... | CAS号858938-15-5 (+/-)-trans-4-(... | CAS号459-32-5 对氟肉桂酸 | CAS号317323-77-6 4-(4-氟苯)-1-甲基-3... | CAS号61869-08-7 帕罗西汀 | CAS号600135-83-9 (3S,4R)-4-(4-Fl... | CAS号608521-21-7 Paroxol Methane... | CAS号110429-35-1 盐酸帕罗西汀半水合物 | CAS号110429-36-2 甲基帕罗西汀

对氟肉桂酸置于4-二甲氨基吡啶,Lithium Aluminium Tetrahydride,Sodium Hydride,三乙胺体系中,用 四氢呋喃,二氯甲烷,二甲基亚砜,甲苯 用作溶剂,化学反应 2.33H,反应生成反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶
参考文献:An Efficient And Stereoselective Synthesis Of (3S,4R)-(−)-Trans-4-(4'-Fluorophenyl)-3-Hydroxymethyl-N-Methylpiperidine
标题:An Efficient And Stereoselective Synthesis Of (3S,4R)-(−)-Trans-4-(4'-Fluorophenyl)-3-Hydroxymethyl-N-Methylpiperidine
摘要:An Asymmetric Conjugate Addition Reaction Between A Chiral Alpha,Beta-Unsaturated Amido Ester And Ethyl-N-Methylmalonamide Has Been Used As A Key Step In The Synthesis Of (3S,4R)-(-)-Trans-4-(4'-Fluorophenyl)-3-Hydroxymethyl-N-Methylpiperidine,A Key Intermediate For (-)-Paroxetine. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2010.12.020

专利信息

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-2001053862-A1
优先权日:1998-12-22
标 题:Process for preparing arylpiperidine carbinol intermediates and derivatives
发明人：RONSEN BRUCE; UPADHYAYA SUBHASH P
摘要:A process for the synthesis of arylpiperidine carbinol intermediates and derivatives is disclosed. A preferred process embodiment provides the synthesis of intermediate compounds of structural formula (I) and structural formula (II): n n n where X is halo, C 1 -C 10 alkoxy, C 1 -C 10 haloalkyl, or hydroxy; R 2 and R 3 are each C 1 -C 4 alkyl, and R 2 and R 3 are the same. The compound of structural formula (I) is made by condensing a corresponding cinnamonitrile with a corresponding diester malonate. The compound of structural formula (II) in the (±)-trans configuration is obtained by hydrogenating the compound of structural formula (I). The compounds of structural formula (I) and structural formula (II) are useful chemical intermediates for synthesizing 4-arylpiperidine-3-carbinols and their derivatives in (−)-trans configuration.

专利号:WO-0037443-A1
优先权日:1998-12-22
标 题 :Process for preparing arylpiperidine carbinol intermediates and derivatives
发明人：RONSEN BRUCE; UPADHYAYA SUBHASH P
权利人:PENTECH PHARMACEUTICALS INC
摘要:A process for the synthesis of arylpiperidine carbinol intermediates and derivatives is disclosed. A preferred process embodiment provides the synthesis of intermediate compounds of structural formula (I) and structural formula (II), where X is halogen, C1-C10 alkyl, C1-C10 alkoxy, C1-C10 haloalkyl, hydroxy, or hydrogen; and R2 and R3 each is C1-C4 alkyl and R2 and R3 are the same. The compound of structural formula (I) is made by condensing a corresponding cinnamonitrile with a corresponding diester malonate. The compound of structural formula (II) in the (±)-trans configuration is obtained by hydrogenating the compound of structural formula (I). The compounds of structural formula (I) and structural formula (II) are useful chemical intermediates for synthesizing 4-arylpiperidine-3-carbinols and their derivatives in (-)-trans configuration.

专利号:WO-2009035652-A1
优先权日:2007-09-13
标 题 :Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof

专利号:US-2014336387-A1
优先权日:2007-09-13
标题:Synthesis of deuterated catechols and benzo[d][1,3]dioxoles and derivatives thereof

专利号:EP-2200997-B9
优先权日:2007-09-13
标 题:Synthesis of deuterated benzodioxoles