CAS: 960608-17-7; (S)-5-(((S)-6-Amino-1-((Carboxymethyl)Amino)-1-Oxohexan-2-yl)Amino)-4-(2-Aminoacetamido)-5-Oxopentanoic Acid

专利信息

专利号:US-6699981-B2
优先权日:1999-09-22
标题 :Method and compositions for improved polynucleotide synthesis
发明人：YANG SHUWEI
权利人:GENECOPOEIA INC
摘要:The sensitivity and specificity of polynucleotide synthesis is increased by protecting the 3'-end of an oligonucleotide used as a primer in the synthesis of the polynucleotide. Protection of the 3'-end of an oligonucleotide prevents non-specific chain elongation. Removal of blocking group an elevated temperature, using a thermostable enzyme, permits template-specific polynucleotide synthesis. The present invention also provides oligonucleotides with a 3' end protected by a blocking group and a thermostable enzyme capable of removing the blocking group at an elevated temperature. The compositions and methods of the invention are very useful in a variety of techniques for DNA/RNA amplification and analysis, including medical genetics research and diagnosis, pathogen detection, forensic, and animal and plant genetics applications, among others.

专利号:US-2004219645-A1
优先权日:1999-05-28
标题 :Polyketides and their synthesis
发明人：LEADLEY PETER FRANCIS; STAUNTON JAMES; OLIYNYK MARK YAN
权利人:LEADLEY PETER FRANCIS; STAUNTON JAMES; OLIYNYK MARK YAN
摘要:The complete sequence of the gene cluster for the monensin type I polyketide synthase, from S. cinnamonensis, is provided. Thus variant polyketides containing monensin-derived elements can be genetically engineered. Furthermore there are novel features, e.g. a regulatory protein mon RI, which are of wide utility.

专利号:AU-2007258387-B2
优先权日:2006-06-13
标 题 :Peptide fragments for inducing synthesis of extracellular matrix proteins

专利号:US-5925733-A
优先权日:1995-07-14
标 题 :DNA polymerase of gamma herpes viruses associated with Kaposi's sarcoma and retroperitoneal fibromatosis
发明人：ROSE TIMOTHY M; BOSCH MARNIX L; STRAND KURT; TODARO GEORGE J
权利人:UNIV WASHINGTON
摘要:This invention provides isolated polynucleotides encoding DNA polymerases of three members of a subfamily of gamma herpes viruses. Two were obtained from macaque monkeys affected with retroperitoneal fibromatosis, the other from human AIDS patients affected with Kaposi's sarcoma. A 454-base pair fragment encoding a region near the active site of the DNA polymerase is 69-83% identical amongst the three viruses, but only 54-68% identical with other known gamma herpes sequences and <55% identical with alpha and beta herpes sequences. Also provided are polynucleotides encoding DNA polymerase from related viruses in the RFHV/KSHV subfamily. Polynucleotides prepared according to the sequence data can be used as reagents to detect and characterize related sequences. Such reagents may be used to detect members of the RFHV/KSHV subfamily, including but not limited to RFHV, RFHV2, and KSHV. Corresponding polypeptides and peptide fragments may be obtained by expressing the polynucleotide or by chemical synthesis. They may be used for detecting specific antibody potentially present in the serum of infected subjects. They may also be used for designing or screening pharmaceutical compounds that limit viral replication by inhibiting DNA polymerase activity.

专利号:US-2007299015-A1
优先权日:2006-06-13
标题 :Peptide fragments for inducing synthesis of extracellular matrix proteins

专利号:US-2014066380-A1
优先权日:2006-06-13
标题:Peptide fragments for inducing synthesis of extracellular matrix proteins