CAS: 866319-00-8; 5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine
该化合物是热循环有机化合物,其特点是其引信的火花和环,具有独特的化学特性; 5位置上存在氟原子会增强其反应力,并可能影响其生物活动,使其对药用化学感兴趣; 这种化合物通常会显示一种能够促进与生物目标互动的平板结构; 它的分子框架允许药物开发的潜在应用,特别是在针对各种疾病的药品设计中. 这种化合物很可能溶于有机溶剂,其再活动可能受到氟化亚体的电吸附性质的影响. 此外,它可能根据情况,经历各种化学反应,例如核球菌替代或电动药用添加.
相似化合物
640735-23-5 1190309-71-7 866318-99-2物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号866319-01-9 5-氟-3-((三甲基甲硅烷基... | CAS号868387-37-5 5-氟-1-三异丙基甲硅烷基-... | CAS号936344-74-0 3-乙炔基-5-氟吡啶-2-胺 | CAS号183208-35-7 5-溴-7-氮杂吲哚 | CAS号1190321-96-0 6-氯-5-氟-1H-吡咯并[... | CAS号1171920-17-4 5-氟-1H-吡咯并[2,3-... | CAS号866318-98-1 5-Fluoro-2-iodo... | CAS号866318-99-2 5-氟-1-[(4-甲基苯基)... | CAS号882033-65-0 5-氟-1H-吡咯并[2,3-...合成工艺路线路线简述
- 868387-37-5 = 866319-00-8
反应条件:1.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; Rt
标题:The Optimization Of Aminooxadiazoles As Orally Active Inhibitors Of Cdc7
作者:Harrington,Paul E.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2013 卷标:23(23) 页码:6396-6400
📜5-溴-7-氮杂吲哚置于正丁基锂,四丁基氟化铵,Sodium Hydride,N-氟代双苯磺酰胺体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 5-氟-1H-吡咯并[2,3-B]吡啶
参考文献:The Optimization Of Aminooxadiazoles As Orally Active Inhibitors Of Cdc7
标题:The Optimization Of Aminooxadiazoles As Orally Active Inhibitors Of Cdc7
摘要:A Series Of Aminooxadiazoles Was Optimized For Inhibition Of Cdc7. Early Lead Isoquinoline 1 Suffered From Modest Cell Potency (Cellular Ic50 = 0.71 Mu M Measuring Pmcm2),Low Selectivity Against Structurally Related Kinases,And High Iv Clearance In Rats (Cl = 18 L/h/kg). Extensive Optimization Resulted In Azaindole 26 (Cdc7 Ic50 = 1.1 Nm,Pmcm2 Ic50 = 32 Nm) That Demonstrated Robust Lowering Of Pmcm2 In A Mouse Pharmacodynamic (Pd) Model When Dosed Orally. Modifications To Improve The Pharmacokinetic Profile Of This Series Were Guided By Trapping Experiments With Glutathione In Rat Hepatocytes. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2013.09.055
海关参考信息
- 2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2006183758-A1
优先权日:2005-02-17
标 题:Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
发明人：BEARD CHARLES D; LEE VING J; WHITTLE C E
权利人:CB RES AND DEV INC
摘要:Methods of synthesis of intermediates that are useful as bioisosteres of the indole, benzofuran and benzothiophene scaffold are disclosed.
专利号:US-12415804-B2
优先权日:2023-06-28
标题 :Compounds for activating a serotonin receptor
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
专利号:US-2025163044-A1
优先权日:2021-12-24
标 题:Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLAM; TAN JINLONG
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
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合成参考文献
参考文献:10.1038/s42004-025-01795-6
摘要:Kowalewski J, Deutscher R, Richardoz M, Tomaszczyk M, Gelin M, Labesse G, Hausch F, Wright GD, Dunyach-Remy C, Guichou JF, Lionne C. Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates. Commun Chem. 2025 Nov 27;8(1):417.
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