CAS: 67473-36-3; 2-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-13-Methyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Acetonitrile
该化合物是类固醇的合成衍生物,具体与静态醇的结构有关;其特点是一种类固醇脊柱,具有第17个碳位置的氢氧基,以及第3位置的氯酮组,这是类固醇化合物的特征;乙烯三烯组的存在表明,它有一个可影响其再活性和溶解性的硝基功能组;该化合物可能展示生物活动,由于与天然类固醇的结构相似,可能与激素受体发生相互作用;其应用可以在药用化学领域,特别是在发展与激素有关的疗法方面加以探索;与许多类固醇衍生物一样,重要的是谨慎地处理这一化合物,考虑到其潜在的生物影响以及在实验室环境中需要适当的安全规程.
- 英文名称2-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-13-Methyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Acetonitrile
- 中文名称17α-氰基甲基-19-去甲睾酮
- IUPAC名称2-((8R,9S,10R,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile
- 其它别名17 Alpha-Cyanomethyl-19-Nortestosterone; 19-Norpregn-4-Ene-21-Nitrile, 17-Hydroxy-3-Oxo-, (17α)- (9Ci); Dienogest Impurity 9 (Dienogest Ep Impurity F); 17A-Cyanomethyl-19-Nortestosterone; 17α-Cyanomethyl-19-Nortestosterone; （17α-Cyanomethyl-17β-Hydroxy-Estra-4-En-3-One）; (17-Hydroxy-3-Oxoestr-4-En-17α-yl)Acetonitrile,; Dinoregin Impurity F
- CAS编号67473-36-3
- MFCD编号:MFCD34472963
- FDA UNII编号:RJA74WRD3Y
- 分子式:C20H27NO2分子量:313.44
- 产品CID: 1657482
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
(10)-estradiene-17S-spiro-oxirane3-methoxy-2,5(10)-estradiene-17S-spiro-oxirane 3-methoxy-19-norandrosta-3,5-dien-17-one 2-((8R,9S,13S,14S,17R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)acetonitrile合成工艺路线路线简述
- 合成目标产物 17 Alpha-Cyanomethyl-19-Nortestosterone 主要起始原料 Estra-3,5-Dien-17-One, 3-Methoxy-
- (文献来源)合成步骤主要原料 Estra-3,5-Dien-17-One, 3-Methoxy-
📜17α-Cyanomethyl-13β-Methyl-3-Methoxy-Gona-2,5(10)-Dien-17β-Ol置于盐酸体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 17Alpha-氰基甲基-19-去甲睾酮
参考文献:Ponsold; Huebner; Schade,Pharmazie,1978,Vol. 33,# 12,P. 792-798
标题:Ponsold; Huebner; Schade,Pharmazie,1978,Vol. 33,# 12,P. 792-798
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5438134-A
优先权日:1990-07-09
标 题:Process for the production of unsaturated 17 α-cyanomethyl-17 β-h
发明人：TEICHMUELLER GERHARD; MUELLER GERD
权利人:JENAPHARM GMBH
摘要:The unsaturated 17α-cyanomethyl-17β-hydroxy steroids of the formula I, ##STR1## in which R 1 =Me, Eth; R 2 =H, Me; R 3 =H, OH, an acetoxy or alkoxy group; R 4 =H, R 5 =OH, an acetoxy, alkoxy group of R 4 and R 5 together represent a keto- or ketal group and double bonds are contained in the basic structure of the steroid, particularly between the 15 and 16 position in the steroid ring, from unsaturated 17-ketosteroids of the general formula II as described herein with the aforementioned meanings of R 1 to R 5 by reacting the unsaturated 17-ketosteroids with LiCH 2 CN and subsequently hydrolyzing. n The compounds of formula I are pharmacologically interesting steroid compounds or also intermediate products for the synthesis of highly-effective steroid products which can be used in human and veterinary medicine for the treatment of endocrine disorders and for reproductive control based on their specific hormonal/anti-hormonal actions. n The compounds are suitable for the treatment of endometriosis and also in combination with preparations with ethinylestradiol for fertility control.
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主要参考文献
参考标题:Process For The Production Of Unsaturated 17 .Alpha.-Cyanomethyl-17 .Beta.-摘要:The Unsaturated 17.Alpha.-Cyanomethyl-17.Beta.-Hydroxy Steroids Of The Formula I, ##str1## In Which R.Sub.1 =me, Eth; R.Sub.2 =h, Me; R.Sub.3 =h, Oh, An Acetoxy Or Alkoxy Group; R.Sub.4 =h, R.Sub.5 =oh, An Acetoxy, Alkoxy Group Of R.Sub.4 And R.Sub.5 Together Represent A Keto- Or Ketal Group And Double Bonds Are Contained In The Basic Structure Of The Steroid, Particularly Between The 15 And 16 Position In The Steroid Ring, From Unsaturated 17-Ketosteroids Of The General Formula Ii As Described Herein With The Aforementioned Meanings Of R.Sub.1 To R.Sub.5 By Reacting The Unsaturated 17-Ketosteroids With Lich.Sub.2 Cn And Subsequently Hydrolyzing. The Compounds Of Formula I Are Pharmacologically Interesting Steroid Compounds Or Also Intermediate Products For The Synthesis Of Highly-Effective Steroid Products Which Can Be Used In Human And Veterinary Medicine For The Treatment Of Endocrine Disorders And For Reproductive Control Based On Their Specific Hormonal/anti-Hormonal Actions. The Compounds Are Suitable For The Treatment Of Endometriosis And Also In Combination With Preparations With Ethinylestradiol For Fertility Control.
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