CAS: 66121-71-9; 4-Cyano-1-Methylpyrazole

相似化合物

121358-86-9 25016-11-9 5952-92-1

上下游产品

CAS号70910-18-8 4-Cyan-1-methyl... | CAS号60-34-4 甲基肼 | CAS号43193-15-3 1H-Pyrazole-4-c... | CAS号5334-41-8 1-甲基-4-氰基-5-氨基-... | CAS号25016-11-9 1-甲基-1H-吡唑-4-甲醛 | CAS号79080-32-3 2-(methylaminom... | CAS号66121-69-5 1-甲基-1H-咪唑-4-甲腈 | CAS号66121-66-2 1-甲基-1H-咪唑-5-腈

1-甲基-1H-吡唑-4-甲醛置于盐酸羟胺,乙酸酐,Potassium Hydroxide体系中,用 乙醇,水 作为反应溶剂,化学反应 1.0H,反应生成 1-甲基-1H-吡唑-4-腈
参考文献:吡唑-4-甲醛甲醛肟的合成,结构与性质
标题:吡唑-4-甲醛甲醛肟的合成,结构与性质
摘要:1-烷基-1 H-吡唑-4-甲醛甲醛肟与乙酸酐反应反应生成相应的腈,这对于醛肟的反异构体来说是典型的.通过x射线分析确定了晶体中5-甲基-1-丙基-1 H-吡唑-4-甲醛甲醛的抗构型.
DOI:10.1134/s1070363212100131

专利信息

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:WO-2015095767-A1
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof