CAS: 637-44-5; 3-Phenylpropiolic Acid

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CAS号591-50-4 碘苯 | CAS号471-25-0 丙炔酸 | CAS号124-38-9 二氧化碳 | CAS号536-74-3 苯乙炔 | CAS号1504-58-1 3-苯基-2-丙炔-1-醇 | CAS号2216-94-6 苯基丙炔酸乙酯 | CAS号108-86-1 溴苯 | CAS号2579-22-8 苯丙炔醛 | CAS号6738-06-3 溴化苯基乙炔基镁 | CAS号2170-06-1 1-苯基-2-(三甲基硅)乙炔 | CAS号1019-90-5 5-chloro-2-phen... | CAS号104213-86-7 (4-methoxypheny... | CAS号108-02-1 卡普他明 | CAS号107182-31-0 N-(2-methyl-1-o... | CAS号1015-02-7 1-(3-phenylprop... | CAS号107451-76-3 1,5-diphenylpen... | CAS号104505-69-3 4-methoxy-2-phe... | CAS号110166-71-7 ethyl 2-(2-phen... | CAS号4891-38-7 苯丙炔酸甲酯 | CAS号14143-92-1 2-Propyn-1-one,...

Tert-Butyldiphenylsilyl 3-Phenylpropiolate置于四溴化碳体系中,用 甲醇 作为反应溶剂,化学反应 48.5H,以61%的收率获得产物苯丙炔酸
参考文献:三烷基甲硅烷基酯的溶剂调节化学选择性脱保护和化学选择性酯化
标题:三烷基甲硅烷基酯的溶剂调节化学选择性脱保护和化学选择性酯化
摘要:在醇反应体系中,在催化量的cbr 4下,将一系列的三烷基甲硅烷基酯脱保护或酯交换成它们相应的羧酸或甲酯.该方法使得能够将仲sp 3-碳,Sp 2-碳,Sp-碳和芳基系链的三烷基甲硅烷基酯脱甲硅烷基化为羧酸,而将sp 3-碳系链的三烷基甲硅烷基酯进一步在cbr 4 / Meoh反应下转化为它们的甲酯.情况.在这种光化学诱导的反应条件下,可以通过引入的保护三烷基甲硅烷基和所用的醇如meoh和etoh来调节和实现高度化学选择性的脱保护.
DOI:10.1016/j.Tetlet.2005.07.049

专利信息

专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人：OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-11414375-B2
优先权日:2016-07-29
标题:Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide
发明人：ZHAO JUNFENG; HU LONG; XU SILIN; ZHAO ZHENGUANG
权利人:UNIV JIANGXI NORMAL
摘要:Disclosed are a mild and efficient preparation method for an α-acyloxyenamide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxyenamide compound is obtained by an addition reaction of a ynamide and a carboxylic acid in dichloromethane under conditions where the temperature is 0° C. to 50° C.; the produced α-acyloxyenamide compound can react with an amine compound to produce an amide or a polypeptide; the two reactions can be carried out step by step, and can also be carried out in one pot. According to the invention, the reaction conditions are mild and no metal catalyst is required; when the carboxylic acid, which has chirality on an alpha site of carboxyl, forms an amide bond or a peptide bond, no racemization occurs; and the operation is simple and the application range is wide.

专利号:EP-0255715-B1
优先权日:1986-08-07
标题 :Process for the synthesis of heterocycles from palladocyclic complexes
摘要:Heterocylic rings are synthesised from palladocyclic complexes by reaction with alkynes, characterised in that the palladocyclic complexes are employed in the form of iodo or cationic complexes. The process applies in particular to the synthesis of nitrogenous heterocyclic rings.

专利号:WO-2023284262-A1
优先权日:2021-07-13
标 题 :3,4-fused seven-membered heterocyclic oxindole, synthesis method therefor and application thereof
发明人：Li shuai-shuai; HU FANGZHI; Ding Zhanshuai; LI XINYAO
权利人:UNIV QINGDAO AGRICULTURAL
摘要:Disclosed is a 3,4-fused seven-membered heterocyclic oxindole, a synthesis method therefor and an application thereof. A structure of a 3,4-fused seven-membered nitrogen heterocyclic oxindole is provided in the present invention. A method for synthesizing same is also provided, comprising the following steps: reacting propargyl alcohol containing an isatin framework with a nucleophile under specific conditions to prepare a 3,4-fused seven-membered nitrogen heterocyclic oxindole. A pharmaceutical composition is provided in the present invention. Also provided in the present invention is an application of a 3,4-fused seven-membered nitrogen heterocyclic oxindole in the preparation of a drug for treating cancer. Provided in the present invention is a method for efficiently synthesizing 3,4-fused seven-membered nitrogen heterocyclic oxindoles having different structures. This is the first time achieving efficient synthesis of bioactive molecules containing both benzazepine and 3,4-fused heterooxidized oxindole structures on the basis of a hydrogen migration strategy.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-2024124910-A1
优先权日:2021-02-02
标题:Ribosome-mediated polymerization of novel chemistries
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; ANSLYN ERIC V; CORONADO JAIME; LIM JONGDOO
权利人:UNIV NORTHWESTERN; UNIV TEXAS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.