CAS: 63208-82-2; 2-(2-Imino-4,5,6,7-Tetrahydrobenzothiazol-3-yl)-1-P-Tolylethanone Hydrobromide

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CAS号2933-29-1 2-氨基-4,5,6,7-四氢苯并噻唑 | CAS号619-41-0 2-溴-4'-甲基苯乙酮 | CAS号55895-83-5 IFLAB-BB F0017-0190 | CAS号108-94-1 环己酮

📜环己酮置于碘体系中,用 苯 作为反应溶剂,化学反应 54.0H,反应生成 2-(2-亚氨基-4,5,6,7-四氢苯并噻唑-3-基)-1-P-苯甲基乙酮氢溴酸盐
参考文献: Pifithrin Analogues And Methods Of Treating Rett Syndrome[fr] Analogues De Pifithrine Et Méthodes De Traitement Du Syndrome De Rett
标题: Pifithrin Analogues And Methods Of Treating Rett Syndrome[fr] Analogues De Pifithrine Et Méthodes De Traitement Du Syndrome De Rett
摘要:本文披露了pifithrin化合物,治疗雷特综合征的方法,包括脑融合器官样体,其中包括大脑皮层(cx)器官样体和神经节突起(ge)器官样体之间的融合,其中一个器官样体包括,基本上由或完全由在甲基-Cpg结合蛋白2(mecp2)基因中具有功能丧失突变的神经细胞,并且使用脑融合器官样体来筛选治疗,减少或抑制由mecp2突变引起的异常神经活动的候选化合物的方法.

专利信息

专利号:WO-2011045374-A1
优先权日:2009-10-15
标 题 :Model-guided random assembly pcr for the synthesis of eukaryotic promoters
发明人：REIS YARA; RICHTER DANIELA; REICHENZELLER MICHAELA; IWAMOTO NAO; ZHU CHENCHEN; UCKELMANN HANNAH; EILS ROLAND; KEIENBURG JENS; HUNDESHAGEN PHILIPP; BERNARDO MARTI; BAUER TOBIAS; KRANZ ANNA-LENA; KOENIG RAINER; HEINEMANN TIM; MUGAHID DOUAA; VELTEN LARS; HAAS SIMON; HILLER CORINNA; BARTOSCHEK MICHAEL; RADEMACHER ANNE; MEYER HANNAH; KRAEMER STEPHEN; ZHAO BINGGING
权利人:DEUTSCHES KREBSFORSCH; UNIV RUPRECHT KARLS HEIDELBERG; REIS YARA; RICHTER DANIELA; REICHENZELLER MICHAELA; IWAMOTO NAO; ZHU CHENCHEN; UCKELMANN HANNAH; EILS ROLAND; KEIENBURG JENS; HUNDESHAGEN PHILIPP; BERNARDO MARTI; BAUER TOBIAS; KRANZ ANNA-LENA; KOENIG RAINER; HEINEMANN TIM; MUGAHID DOUAA; VELTEN LARS; HAAS SIMON; HILLER CORINNA; BARTOSCHEK MICHAEL; RADEMACHER ANNE; MEYER HANNAH; KRAEMER STEPHEN; ZHAO BINGGING
摘要:The current invention is concerned with a method for the manufacture of a polynucleotide comprising a synthetic promoter specifically controlled by at least one selected transcription factor, comprising a) determining the distance between the transcriptional start point and the binding site for said at least one transcription factor in a given number of promoters comprising at least one binding site for said at least one transcription factor, b) selecting a distance range comprising the distances determined in a) to occur most frequently, c) determining the accompanying transcription factors in a given number of promoters, d) selecting a suitable number of accompanying transcription factors determined in c) to occur most frequently, e) synthesizing the synthetic promoter by randomly assembling i) at least one binding site for each of the at least one transcription factor, ii) at least one binding site for each of the selected accompanying transcription factor(s), and iii) a suitable number of stuffer fragments and by arranging said randomly assembled binding sites in the distance range from the transcriptional start point selected in b). The invention is further concerned with a polynucleotide comprising the synthetic promoter manufactured by the method of the current invention, a vector comprising the polynucleotide of the current invention, and a cell comprising the polynucleotide or the vector of the current invention. Furthermore, the invention relates to a device for the manufacture of oligonucleotides suitable for manufacturing a synthetic promoter of the current invention and a device for the manufacture of the synthetic promoter of the current invention.