CAS: 621-37-4; 3-Hydroxyphenylacetic Acid

上下游产品

CAS号121-71-1 3-羟基苯乙酮 | CAS号156945-58-3 [3-(allyloxy)ph... | CAS号1798-09-0 3-甲氧基苯乙酸 | CAS号13398-94-2 2-(3-羟基苯基)乙醇 | CAS号2861-28-1 2-(苯并[d][1,3]二氧... | CAS号53313-95-4 3-HYDROXYM AND ... | CAS号103-82-2 苯乙酸 | CAS号124-38-9 二氧化碳 | CAS号108-39-4 间甲酚 | CAS号25263-44-9 (3-羟苯基)乙腈 | CAS号52798-00-2 2-(3-氰基苯基)乙酸甲酯 | CAS号146031-94-9 2-(3-异丙氧基苯基)乙酸 | CAS号42058-59-3 3-羟基苯乙酸甲酯 | CAS号106-49-0 对甲苯胺 | CAS号102-32-9 3,4-二羟基苯乙酸 | CAS号451-13-8 尿黑酸，高龙胆酸 | CAS号295320-25-1 苄基-3-羟基苯基乙酸酯 | CAS号1860-58-8 3-苄氧基苯乙酸 | CAS号6834-42-0 3-甲氧基苯基乙酰氯 | CAS号66622-47-7 2-(3-异丁基苯基)丙酸

3-碘苯乙酸置于copper(I) Oxide,1-D-O-Methyl-Chiro-Inositol,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 6.0H,以71%的收率获得产物3-羟基苯乙酸
参考文献:铜和1-(-)-邻苯二酚在空气中催化芳基卤化物的羟基化和胺化
标题:铜和1-(-)-邻苯二酚在空气中催化芳基卤化物的羟基化和胺化
摘要:1-(-)-木瓜醇,一种从橡胶工业废水中获得的天然产物,被用作铜催化的羟基卤化和芳基卤化物胺化的有效配体,以选择性地在水中或95%的乙醇中反应生成酚和芳基胺.另外,在空气中以100G的规模验证了2-氯-4-羟基苯甲酸的羟基化.
DOI:10.1016/j.Tetlet.2020.152222

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-4334079-A
优先权日:1980-11-03
标 题:Synthesis of substituted benzyl esters
发明人：GREENE JAMES M; BUNNELL CHARLES A
权利人:LILLY CO ELI
摘要:A process for preparing certain substituted benzyl esters of phenylacetic acids by esterification in a solvent in which the salt of the acid is insoluble, and in the presence of a phase transfer catalyst.

专利号:US-2002045220-A1
优先权日:1999-10-13
标题:Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. col. This achievement permits a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.