CAS: 529-53-3; 5,6,7-Trihydroxy-2-(4-Hydroxyphenyl)-4H-Chromen-4-One

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CAS号27740-01-8 野黄芩苷 | CAS号1168-42-9 4',5,6,7-四甲氧基黄酮 | CAS号520-36-5 芹菜素; 芹黄素; 5,7,4... | CAS号19103-54-9 三裂鼠尾草素 | CAS号41440-05-5 8-羟基芹菜素 | CAS号6563-66-2 5,6,7-trihydrox... | CAS号480-66-0 2',4',6'-三羟基苯乙酮 | CAS号100-07-2 对甲氧基苯甲酰氯 | CAS号480-41-1 柚皮素； 4',5,7-三羟基黄烷酮 | CAS号19103-54-9 三裂鼠尾草素 | CAS号21450-56-6 1,2,3,4-四甲氧基苯 | CAS号99-93-4 对羟基苯乙酮 | CAS号99-96-7 4-羟基苯甲酸 | CAS号108-73-6 间苯三酚 | CAS号1019-52-9 3,5-二硝基-4-羟基苯甲酸 | CAS号144-62-7 草酸 | CAS号88-89-1 苦味酸 | CAS号27740-01-8 野黄芩苷 | CAS号6563-66-2 5,6,7-trihydrox...

📜6-Hydroxy-5,7-Dimethoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One置于吡啶盐酸盐体系中,化学反应 6.0H,以2.6 G的收率获得产物野黄芩素
参考文献:黄酮黄酮苷的实用合成
标题:黄酮黄酮苷的实用合成
摘要:使用可用且廉价的 2,6-二甲氧基-1,4-苯醌作为起始原料,以 60% 的总收率实现了实用且经济的黄酮黄酮五步合成.反应顺序包括还原为相应的醌醇,Friedel-Crafts 乙酰化,Claisen-Schmidt 与对甲氧基苯甲醛缩合,环化和去甲基化.该程序操作简单,适合放大合成.
DOI:10.3184/174751917X14873588907765

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:US-2024336679-A1
优先权日:2021-08-06
标题 :Methods for the treatment of cancer
发明人：LINARES LÆTITIA; FIRMIN NELLY; MANTEAUX GABRIELLE
权利人:INST REGIONAL CANCER MONTPELLIER; INST NAT SANTE RECH MED; UNIV MONTPELLIER
摘要:The present disclosure relates to an Interleukin-6 (IL-6) signaling inhibitor selected from an IL-6 inhibitor, an IL-6 receptor inhibitor, an IL-6/IL-6 receptor complex inhibitor, a gp130 inhibitor and a STAT3 inhibitor or a pharmaceutical composition comprising such an IL-6 signaling inhibitor. for use in a method for treating and/or preventing cancer in a subject in need thereof. wherein the subject has been previously classified as being affected with a cancer exhibiting recruitment of MDM2 to chromatin. The inventors have observed that cancers exhibiting recruitment of MDM2 to chromatin have been shown to secrete IL-6 that in turn acts on myoblast cells to activate serine synthesis. Following these surprising and unexpected observations. the inventors set up methods of treatment that are able to induce cancer cells death in subjects that have been previously classified as being affected with a cancer exhibiting recruitment of MDM2 to chromatin.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:US-11896961-B1
优先权日:2022-09-07
标题 :Optimization of photocatalytic hydrogen generation using aqueous bio-alcohols and plasmonic metals deposited on semiconductor composite nanofibers
发明人：JAWHARI AHMED HUSSAIN; RADINI IBRAHIM ALI; HASAN NAZIM; MALIK MAQSOOD AHMAD; NARASIMHARAO KATABATHINI
权利人:JAZAN UNIV
摘要:The present invention combines the advantages of fabrication of semiconductor heterostructure (Ag3PO4—WO3) with plasmonic metals (Pt and Ag) with optical interference to optimize the visible light photo response of plasmonic metals deposited semiconductor (Pt—Ag/Ag3PO4—WO3) for visible light assisted H2 generation utilizing the aqueous bio-alcohols. Crystalline Ag3PO4 and WO3 nanofibers were synthesized by microwave and electrospinning methods. Three different WO3 nanofibers composition (5, 10 and 15 wt. %) were used to obtain Ag3PO4/WO3 nanocomposite heterostructures, which are effective visible light active photo catalysts. Further, a simple, enviro-friendly, and cost-effective biogenic synthesis method have been achieved using Salvia officinalis extract to decorate Pt and Ag metal nanoparticles on the surface of Ag3PO4—WO3 composites. Presence of bioactive agents in the extract are responsible for the Pt and Ag3PO4 reduction and for prevention of the Pt nanoparticles from aggregation in aqueous medium.

专利号:US-5643598-A
优先权日:1988-03-09
标 题 :Method of skin care utilizing liposomes containing Scutellaria extracts
发明人：MEYBECK ALAIN
权利人:LVMH RECH
摘要:The invention relates to a composition based on hydrated lipid lamellar phases or liposomes. n This composition is characterized in that said hydrated lipid lamellar phases or said liposomes contain at least in part an extract of Scutellaria, or at least one active substance isolated from such an extract or obtained by chemical synthesis, particularly wogonine, 2'-hydroxy-wogonine, baicaleine, neobaicaleine, oroxindine and baicaline. n This composition is useful for the preparation of cosmetic or pharmaceutical, particularly dermatological compositions, with anti-allergic, anti-inflammatory or anti-ageing activity.