CAS: 450-91-9; 4-Fluoro-2-Methoxyaniline

上下游产品

CAS号448-19-1 5-氟-2-硝基苯甲醚 | CAS号7440-02-0 镍 | CAS号446-36-6 5-氟-2-硝基苯酚 | CAS号456-49-5 间氟苯甲醚 | CAS号1075705-01-9 4-氟-2-甲氧基-5-硝基苯胺 | CAS号450-88-4 2-溴-5-氟苯甲醚 | CAS号450-89-5 2-氯-5-氟苯甲醚

间氟苯甲醚置于adam's Catalyst 氢气,硝酸,乙酸酐体系中,化学反应生成 4-氟-2-邻甲氧基苯胺
参考文献:Fragmentation Selectivity In Electron Impact Ionization Mass Spectra Of Substituted Dimethoxybenzenes
标题:Fragmentation Selectivity In Electron Impact Ionization Mass Spectra Of Substituted Dimethoxybenzenes
摘要:Abstractseveral 1‐x‐sabstitirted‐3‐methoxy‐4‐trideuteromethoxybenzens Were Synthesized And Their Electron Impact Ionization Mass Spectra Were Measured With An Ionizing Energy Of 20 Ev. From The Peak Intensity Ratio Of [m  Cd3] And [m  Ch3] The Fragmentation‐directing Ability Of The Substituent X Was Evaluated. The Most Powerful Group Was Found To Be Nh2,Which Expelled A Methoxy Methyl Group Only From Its Para Position. The Ch3 Group And Four Halogen Atoms,F,Cl,Br And I,Exerted A Moderate Effect Electron‐withdrawing Groups Such As No2,Cho And Cn Had Only A Little Influence On The Fragmentation Selectivity. These Results Were Interpreted In Terms Of The Effect Of X On The Distribution Of Both The Unpaired Electron And The Positive Charge In The Molecular Ion.
DOI:10.1002/oms.1210270613

专利信息

专利号:US-2022281888-A1
优先权日:2019-09-25
标题:Bicyclic carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT; GORECZNY GREGORY
权利人:NIROGY THERAPEUTICS INC
摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:CN-108187666-B
优先权日:2018-01-23
标 题:Preparation of biomass derived palladium catalyst and application of biomass derived palladium catalyst in synthesis of antitumor drug ocitinib

专利号:CN-112341346-B
优先权日:2020-10-30
标 题 :A kind of synthesis method of osimertinib intermediate

专利号:RU-2077535-C1
优先权日:1991-09-18
标 题 :Derivatives of benzanilide, method of their synthesis and pharmaceutical composition exhibiting antagonism to 5-ht1 receptors

专利号:CN-116041203-A
优先权日:2023-02-07
标题:Synthesis method of Orientinib intermediate