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专利信息

专利号:US-6090934-A
优先权日:1996-10-20
标 题:Universal support for the synthesis of oligonucleotides
发明人：KUMAR PRADEEP; GUPTA KAILASH CHAND
权利人:COUNCIL SCIENT IND RES; DBT GOVERNMENT OF INDIA
摘要:A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.

专利号:WO-2019199375-A1
优先权日:2018-04-10
标 题 :Synthesis of boron complexes with oxygen-containing multidentate ligands
发明人：LU GANG
权利人:DOW SILICONES CORP
摘要:A method for preparing a boron complex is provided. The method comprises contacting and allowing to react at a temperature from 0 to 100°C: (a) an alkoxyborane of formula (I) wherein R1 and R2 independently are hydrogen, C1-C30 hydrocarbyl or C5-C30 heterocyclic; and R3 is C1-C30 hydrocarbyl; and (b) either (i) an α-diketo compound having from 4 to 30 carbon atoms, or (ii) a β-diketo compound having from 5 to 50 carbon atoms. A method for addition reaction polymerization using the boron complex obtained by said method is also provided.

专利号:WO-2018145009-A1
优先权日:2017-02-06
标 题 :Dna-zyme based methods & compositions for treating huntington's disease
发明人：POURMOTABBED TAYEBEH; REINER ANTON
权利人:UNIV TENNESSEE RES FOUND
摘要:Provided herein are methods and compositions for treating Huntington's disease. For example, provided are compositions that include DNA oligonucleotides that have targeting specificity for RNA encoding mutant huntingtin protein. When introduced into a cell, the DNA oligonucleotides reduce expression of the mutant huntingtin protein in a cell. For example, the DNA oligonucleotide, functioning as an enzymatic DNA molecule (or DNAzyme), cleaves the RNA encoding the mutant mRNA protein, thereby rendering the mRNA incapable of expression. That is, the cleavage event renders the RNA non¬ functional and reduces or abrogates protein expression from that RNA. Hence, synthesis of the mutant huntingtin protein is selectively reduced or inhibited, in accordance with the methods and compositions described herein. By silencing or reducing the expression of the mutant huntingtin protein, the methods and compositions describe herein can be used to treat Huntington's disease, including adult and juvenile onset Huntington's disease.

专利号:US-5942608-A
优先权日:1996-10-29
标题:Process for preparing a universal support for the synthesis of oligonucleotides

专利号:WO-9320092-A1
优先权日:1992-04-03
标题 :Synthesis of oligonucleotides

专利号:WO-9726270-A2
优先权日:1996-01-16
标 题 :Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules