CAS: 392-71-2; 2,6-Dichloro-4-Fluorophenol

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CAS号371-41-5 4-氟苯酚 | CAS号371-40-4 4-氟苯胺 | CAS号697-91-6 2、6一二氯-P-苯醌 | CAS号392-17-6 2-(2,6-dichloro...

📜4-氟苯酚置于氯体系中,化学反应生成2,6-二氯-4-氟苯酚
参考文献:Aromatic Fluorine Compounds. Viii. Plant Growth Regulators And Intermediates1,2
标题:Aromatic Fluorine Compounds. Viii. Plant Growth Regulators And Intermediates1,2
摘要:
Doi:10.1021/ja01510A021

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5968736-A
优先权日:1992-10-01
标 题 :Methods for recording the reaction history of a solid support
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:COLD SPRING HARBOR LAB; UNIV COLUMBIA
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-6503759-B1
优先权日:1992-10-01
标题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C; WIGLER MICHAEL H
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-5721099-A
优先权日:1992-10-01
标 题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-6001579-A
优先权日:1993-10-01
标 题 :Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:EP-0993428-B1
优先权日:1997-06-24
标 题:Method for chlorinating halogenated phenols
发明人：DESMURS JEAN-ROGER; SPINDLER JEAN-FRANCIS; PADILLA GENEVIEVE
权利人:RHODIA CHIMIE SA
摘要:The invention concerns a method for chlorinating an aromatic ring, characterised in that it consists in submitting the aromatic substrate to the action of a chlorinating agent in the presence of a Lewis acid containing a boron atom bound to at least an oxygen atom. The invention is applicable to organic synthesis.