CAS: 362-74-3; (4Ar,6R,7R,7Ar)-6-(6-Butyramido-9H-Purin-9-yl)-2-Hydroxy-2-Oxidotetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinin-7-Yl Butyrate

上下游产品

butanoic acid anhydride cAMP

丁酸酐,腺苷环磷酸酯置于n,N-二异丙基乙胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 7.0H,以96.09%的收率获得产物二丁酰环磷腺苷
参考文献:一种二丁酰环磷腺苷类化合物及其金属盐的制备方法
标题:一种二丁酰环磷腺苷类化合物及其金属盐的制备方法
摘要:本发明公开了一种二丁酰环磷腺苷类化合物及其金属盐的制备方法.其中,二丁酰环磷腺苷类化合物的制备方法包括以下步骤:非质子溶剂中,在有机碱存在下,所述的如式i所示的环磷腺苷与正丁酸酐进行如下所示的酰化反应得二丁酰环磷腺苷类化合物,所述的二丁酰环磷腺苷类化合物的阴离子如式ii所示,其中,所述的二丁酰环磷腺苷类化合物的阳离子为h

专利信息

专利号:US-6372721-B1
优先权日:1993-12-17
标题:Method for inducing DNA synthesis in neurons
发明人：NEUMAN TOOMAS; SUDA KIKUO; NORNES HOWARD O
权利人:SPINAL CORD SOC
摘要:A method is provided for inducing DNA synthesis in differentiated neurons. According to certain embodiments of the invention, a method for inducing DNA synthesis in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.

专利号:US-4780406-A
优先权日:1983-10-18
标题:Flow cytometric measurement of total DNA and incorporated halodeoxyuridine
发明人：DOLBEARE FRANK A; GRAY JOE W
权利人:UNIV CALIFORNIA
摘要:A method for the simultaneous flow cytometric measurement of the total DNA content and the level of DNA synthesis in normal and malignant cells is disclosed. The sensitivity of the method allows a study of cell cycle traverse rates for large scale cell populations as well as single cell measurements. A DNA stain such as propidium iodide or Hoechst 33258 is used as the probe for the measurement of total DNA content and a monoclonal antibody reactive with a DNA precursor such as halodeoxy-uridine (HdU), more specifically bromodeoxyuridine (BrdU) is used as a probe for the measurement of HdU or BrdU uptake by the cells as a measure of DNA synthesis.

专利号:US-4609622-A
优先权日:1983-05-31
标 题:Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line, FRTL-5
发明人：KOHN LEONARD D; VALENTE WILLIAM A; GROLLMAN-WOLFF EVELYN F; ALOJ SALVATORE M; VITTI PAOLO
权利人:INTERTHYR RESEARCH FOUNDATION; UNIV MARYLAND
摘要:A fast growing, continuous, functional rat thyroid cell strain, FRTL-5, which maintains functional characteristics of iodide uptake and thyroglobulin synthesis over prolonged periods of culture is cloned from FRTL cells obtained from primary cultures of Fischer rat thyroid glands. The FRTL-5 cells are cultured in a medium containing approximately 5 percent calf serum supplemented with a mixture of hormones, at least one of which is thyrotropin. n The FRTL-5 cells are employed in a series of assays which measure thyroid stimulatory or inhibitory factors. The FRTL-5 system of assay specifically measures thymidine incorporation, cAMP elevation and iodide uptake and permits the evaluation of patient sera, particularly those afflicted with Graves' disease and other autoimmune thyroid diseases, thereby providing a means for determining appropriate methods of treatment.

专利号:US-5554359-A
优先权日:1989-12-15
标 题:Pigmentation enhancer and method
发明人：FULLER BRYAN B
权利人:UNIV OKLAHOMA
摘要:A composition comprising a lysosomotropic agent, and optionally phosphodiesterase inhibitors, and/or methylxanthines for increasing synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation. An organ culture system comprising viable human foreskin samples which may be used to test the effects of agents on human skin, including pigmentation enhancers on human skin.

专利号:US-4608341-A
优先权日:1983-05-31
标 题:Living, fast-growing thyroid cell strain, FRTL-5
发明人：AMBESI-IMPIOMBATO FRANCESCO S
权利人:INTERTHYR RESEARCH FOUNDATION
摘要:A fast growing, continuous, functional rat thyroid cell strain, FRTL-5, which maintains functional characteristics of iodide uptake and thyroglobulin synthesis over prolonged periods of culture is cloned from FRTL cells obtained from primary cultures of Fischer rat thyroid glands. The FRTL-5 cells are cultured in a medium containing approximately 5 percent calf serum supplemented with a mixture of hormones, at least one of which is thyrotropin. The FRTL-5 cells are employed in a series of assays which measure thyroid stimulatory or inhibitory factors. The FRTL-5 system of assay specifically measures thymidine incorporation, cAMP elevation and iodide uptake and permits the evaluation of patient sera, particularly those afflicted with Graves' disease and other autoimmune thyroid diseases, thereby providing a means for determining appropriate methods of treatment.

专利号:WO-2004046348-A1
优先权日:2002-11-17
标题:Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
发明人：OFFEN DANIEL; MELAMED ELDAD; LEVY YOSEF
权利人:UNIV RAMOT; OFFEN DANIEL; MELAMED ELDAD; LEVY YOSEF
摘要:A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.