CAS: 300364-84-5; (E)-2-(3-(4-(Tert-Butyl)Phenyl)-2-Methylallylidene)Malononitrile

专利信息

专利号:WO-2024015528-A1
优先权日:2022-07-15
标题 :Efficient procedure for the synthesis of hydrazone-linked tetrahedral nanocages
发明人：SCHNEEBELI SEVERIN; VESTRHEIM OLAV
权利人:UNIV VERMONT
摘要:The present application is directed to a nanocage of Formula (I): wherein A and R are as described herein. The present application is also directed to an efficient process for preparation of a nanocage of Formula (I), which allows for efficient scale-up of the nanocage synthesis. Furthermore, this new process allows for rapid nanocage diversification, due a newly introduced late-stage functionalization method.

专利号:WO-2025101943-A1
优先权日:2023-11-10
标 题:Nucleic acid-guided dna synthesis
发明人：STERNBERG SAMUEL HENRY; TANG STEPHEN; ZHANG DENNIS JAMES; WIEGAND TANNER; THOMAS GEORGE JERRIN; LAMPE GEORGE DAVIS; KANG SHANNON
权利人:UNIV COLUMBIA
摘要:The present disclosure provides systems, compositions, methods, and kits, for guided DNA synthesis and genome engineering. Particularly, the present disclosure provides systems, compositions, methods, and kits comprising a defense-associated reverse transcriptase (DRT), or a nucleic acid encoding thereof, and an engineered target nucleic acid comprising one or more sequence of interest, or a nucleic acid encoding thereof.

专利号:US-10465044-B2
优先权日:2014-11-18
标 题:Well-defined degradable poly(propylene fumarate) polymers and scalable methods for the synthesis thereof
发明人：BECKER MATTHEW; DEAN HOWARD; LUO YUANYUAN
权利人:BECKER MATTHEW; DEAN HOWARD; LUO YUANYUAN; UNIV AKRON; UNIV OHIO STATE
摘要:Method for making poly(propylene fumarate) (PPF) polymer made by ring-opening polymerization of propylene oxide and maleic anhydride in the presence of magnesium ethoxide initiator, wherein PPF is specifically designed for us in 3D manufacturing of medical devices. PPF polymers have a number average molecular weight (Mn) of from about 450 Daltons to about 3400 Daltons; a molecular mass distribution ( m) of from 1.0 to 2.0; and contains less than 1% w/w of poly(maleic anhydride-co-propylene oxide) polymer chains particularly. PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.

专利号:EP-3736303-A1
优先权日:2019-05-06
标 题:Novel catalyzed synthesis of biodegradable polyesters

专利号:US-12146028-B2
优先权日:2016-06-06
标 题:Iodo-functionalized polymers as mass spectrometry calibrants with a mass-defect offset
发明人：GRAYSON SCOTT M
权利人:THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND; POLYMER FACTORY SWEDEN AB
摘要:The present invention discloses novel calibrants containing between 1 and 5 iodine atoms and methods of making them using linear polymers, hyperbranched polymers, and biological polymers (including but not limited to proteins and peptides.) Methods of using the calibrants are also disclosed, such as mass spectrometry. The novel calibrants disclosed herein have a more cost- and time-efficient synthesis than other calibrants.

专利号:US-10787576-B2
优先权日:2015-04-30
标 题 :Method for the preparation of a coating comprising oligomeric alkynes
发明人：FRAUENRATH HOLGER; SCHRETTL STEPHEN; SCHULTE BJOERN; LETERRIER YVES
权利人:ECOLE POLYTECHNIQUE FED DE LAUSANNE EPFL EPFL TTO
摘要:The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N) x -(L) m -(Câ•?C) n -(L′) o -(N′) y —R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C) n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C 1 -C 25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis ofthe monomers according to the invention.