CAS: 21788-37-4; L-Biotin

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58-85-5 53906-36-8 608-16-2

上下游产品

(+/-)-biotin R)-1( oder !3)-benzyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl]-valeric acid5-[(3aR)-1( oder !3)-benzyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl]-valeric acid H-thieno[3,4-d]imidazol-4-yl)-pentanoic acid5-(2-oxo-2,3-dihydro-1H-thieno[3,4-d]imidazol-4-yl)-pentanoic acid phosgene biotin vitamin H (+/-)-biotin methyl ester 5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (3-phenyl-propyl)-amide

📜1'N-Benzyl Biotin置于氨,Sodium,Xylene体系中,化学反应生成生物素杂质27
参考文献:Synthesis Of Biotin
标题:Synthesis Of Biotin

专利信息

专利号:US-2005009055-A1
优先权日:2002-07-12
标 题 :System and method for examination of microarrays using scanning electron microscope
发明人：CICCOLELLA PAUL C; HOZBOR MARIA A
权利人:AFFYMETRIX INC
摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.

专利号:US-2007249024-A1
优先权日:2004-06-03
标 题:Novel Dna Synthesis Technology with 3'-Beaded Oligo Dna and Dna Polymerase
发明人：MURAISO KANAE
权利人:BISO INFO DESIGN INC
摘要:A method of synthesizing a desired DNA having a predetermined sequence, comprising the steps of (a) preparing, based on the desired DNA, a plurality of 3′-biotin-immobilized oligo DNA having a fixed length; (b) preparing a starting DNA which has a complementary sequence to a 3′ end of a first immobilized oligo DNA of the plurality of oligo DNA, and wherein the starting DNA has a length shorter than the length of the first immobilized oligo DNA; (c) annealing the starting DNA with the first immobilized oligo DNA, extending the starting DNA to complement the first immobilized oligo DNA, thereby making a newly extended DNA; (d) denaturing a first double strand DNA consisting of the newly extended DNA and the first immobilized oligo DNA; (e) collecting the extended DNA by removing the first immobilized oligo DNA from the extended DNA; (f) annealing the collected, extended DNA with a second immobilized oligo DNA from the plurality of oligo DNA, further extending the extended DNA to complement the second oligo DNA, thereby making a further extended DNA; (g) denaturing a second double stranded DNA consisting of the second immobilized oligo DNA and the further extended DNA; (h) collecting the further extended DNA by removing the second immobilized oligo DNA from the extended DNA; and (i) repeating steps (f) through (h) until the further extended DNA becomes the predetermined sequence thereby completing synthesis of the desired DNA.

专利号:US-2004081985-A1
优先权日:2002-07-12
标题:Systems and method for examination of microarrays using scanning electron microscope
发明人：CICCOLELLA PAUL C; HOZBOR MARIA A
权利人:AFFYMETRIX INC
摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.

专利号:US-2009118140-A1
优先权日:2007-03-15
标 题 :Method and system for assembly of macromolecules and nanostructures
发明人：SUZARA VINCENT
权利人:SUZARA VINCENT
摘要:A template-based system enables the assembly of macromolecules and nanostructures. The template system comprises a plurality of single strand DNA molecules which are substantially parallel, substantially inline each from one end, and substantially equally spaced apart, wherein each DNA molecule has a distinguishable length and a known sequence. The system can be used for the precise, accurate, and efficient synthesis of peptides, proteins and enzymes.

专利号:US-4656289-A
优先权日:1984-10-25
标 题 :1,3-dibenzyl-4-halohexahydro-1H-thieno[3,4-d]imidazol-2(3H)-one intermediates
发明人：BATES HANS A; ROSENBLUM STUART
权利人:RES FOUNDATION OF STATE UNIV O
摘要:Novel synthetic routes to (3aα,6aα)-1,3-dibenzyl hexahydro-1H-thieno[3,4-d]imidazol-2(3H)-one 5,5-dioxide, a known intermediate in the synthesis of biotin are provided. n A novel synthetic route from this intermediate to biotin is also disclosed.

专利号:US-8541569-B2
优先权日:2008-09-06
标题:Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3′ end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in 5′→3′ direction, leading to very clean oligo synthesis that allows for the introduction of various modifications at the 3′-end cleanly and efficiently. Higher coupling efficiency per step have been observed during automated oligo synthesis with the reverse RNA amidites disclosed herein, resulting in a greater ability to achieve higher purity and produce very long oligonucleotides. The use of the reverse RNA phosphoramidites in the synthetic process of this invention leads to oligonucleotides free of N+1 species.