CAS: 2177-62-0; H-Asp(Ome)-Oh

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16856-13-6 3160-47-2 59768-74-0

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CAS号67-56-1 甲醇 | CAS号56-84-8 L-天门冬氨酸 | CAS号16856-13-6 L-天冬氨酸-β-甲酯盐酸盐 | CAS号3160-47-2 CBZ-L-天冬氨酸 4-甲酯 | CAS号32213-95-9 L-天冬氨酸二甲酯盐酸盐 | CAS号20859-24-9 (s)-dimethyl br... | CAS号3160-47-2 CBZ-L-天冬氨酸 4-甲酯 | CAS号59768-74-0 B°C-L-天冬氨酸4-甲酯 | CAS号21394-81-0 D-天门冬氨酸-β-甲酯 | CAS号496060-65-2 methyl 3-[(4-me... | CAS号39741-26-9 N-苯甲酰-L-天门冬氨酸-β-甲酯

📜N-(Benzyloxycarbonyl)-L-Aspartic Acid 4-Methyl Ester 反应生成L-天冬氨酸-4-甲酯
参考文献:多肽.第八部分 胃泌素c末端四肽酰胺序列中天冬氨酰位置的变化
标题:多肽.第八部分 胃泌素c末端四肽酰胺序列中天冬氨酰位置的变化
摘要:描述了l-色氨酸-L-甲硫酰基-L-天冬氨酰-L-苯丙氨酸酰胺(胃泌素的c-末端序列)及其n-苄氧羰基或n-叔丁氧羰基衍生物的类似物的合成,其中天冬氨酰残基已被丙氨酰基,β-天冬氨酰,天冬酰胺基,半胱氨酰基,谷氨酰基,甘氨酰基,赖氨酰基,降冰片酰基,鸟氨酸残基,丝氨酰基,苏氨酰基和其他氨基酰基残基取代.
Doi:10.1039/j39680000715

专利信息

专利号:US-6376649-B1
优先权日:1998-12-18
标题 :Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
发明人：SEMPLE JOSEPH E; LEVY ODILE E
权利人:CORVAS INT INC
摘要:Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-alpha-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl alpha-ketoamides and alpha-hydroxy-beta-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases.

专利号:US-2003180804-A1
优先权日:2001-10-29
标题:Solid phase synthesis of chemical libraries
发明人：PRYOR KENT E; LEWIS RONALD D; BROWN JASON W
权利人:CORVAS INT INC
摘要:The present invention provides compounds and compound libraries that are useful as protease modulators. The compounds and compound libraries are preferably made using the methods of the present invention which utilize peptide synthesis and combinatorial chemistry methods on a solid phase.

专利号:US-9121110-B2
优先权日:2002-12-19
标 题 :Quasirandom structure and function guided synthesis methods
发明人：GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS
权利人:GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS; NUEVOLUTION AS
摘要:The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementary connector polynucleotides (CCPNs) harboring at least one functional entity comprising at least one reactive group. At least one of the CCPNs is capable of hybridizing to at least two CPNs. Each CPN will “callâ€? for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of reactive groups results in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNsâ€? to at least one “acceptor CCPNâ€? with which the transferred functional entities were not associated prior to the transfer.

专利号:US-5326908-A
优先权日:1992-12-09
标题:Process for the preparation of asparagine
发明人：ERICKSON ROBERT; BRAY RON; JOHNSON MARK; KLEIN LORAINE; SEAGLE DENNIS A
权利人:ERICKSON ROBERT; BRAY RON; JOHNSON MARK; KLEIN LORAINE; SEAGLE DENNIS A
摘要:The present invention is an improved process for the synthesis of asparagine, a non-essential amino acid useful in food and medical applications. The process utilizes mineral acid to make an intermediate beta-methyl aspartate from a reaction mixture of aspartic acid and methanol. The intermediate product is then amminated in situ and asparagine collected with no need for an isolation step of the intermediates.

专利号:US-6627431-B1
优先权日:2000-05-12
标 题 :Chemoenzymatic synthesis of neotame
发明人：PRAKASH INDRA; ZHAO ROBERT Y
权利人:NUTRASWEET CO
摘要:A chemoenzymatic method is disclosed for preparing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester via the enzymatic regioselective hydrolysis of neotame esters using lipases or esterases.

专利号:WO-0005208-A9
优先权日:1998-07-24
标 题 :Amino-aldehyde solid support, linker therefor and methods of preparation and use thereof
发明人：SIEV DANIEL V; SEMPLE J EDWARD; ROBERTS CHRISTOPHER A
权利人:CORVAS INT INC
摘要:This invention provides a novel method for solid-phase peptide synthesis wherein a cyclic or linear amino aldehyde is derivatized through linkage to a solid-support, and employed in the production of biologically significant peptides, peptide derivatives, peptidomimetic compounds and analogs thereof. The method of linkage and peptide synthesis, including for combinatorial chemistry, is disclosed.