专利号:US-10927139-B2 优先权日:2012-11-22 标 题:Chemically cleavable group 发明人:ROBILLARD MARC STEFAN; VERSTEEGEN RONNY MATHIEU; TEN HOEVE WOLTER; ROSSIN RAFFAELLA 权利人:TAGWORKS PHARMACEUTICALS B V 摘要:Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactive components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine.
专利号:NZ-533287-A 优先权日:2001-11-05 标题:The synthesis of the antihistamine, loratadine, from 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-3-methylpyridine
专利号:US-9771379-B2 优先权日:2015-09-24 标题:N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides 发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS 权利人:PFIZER 摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 , R 2 , R 3 , R 4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-8536164-B2 优先权日:2010-12-20 标 题:Fused pyridine compounds as casein kinase inhibitors 发明人:BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T 权利人:BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T; PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n nand pharmaceutically acceptable salts thereof, wherein X, Y, A, R 4 , n, and R 7 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:CN-1740160-A 优先权日:2005-07-15 标 题 :Synthesis process of loratadine intermediate
专利号:US-9744173-B2 优先权日:2014-04-10 标题 :2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides 发明人:BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; BARREIRO GABRIELA; LACHAPELLE ERIK ALPHIE; ROGERS BRUCE NELSEN 权利人:PFIZER 摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variable R 1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.