CAS: 19309-14-9; (E)-1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-Phenylprop-2-En-1-One

该化合物是天然产生的铬衍生物,主要与Elettaria Cadamomum和其他植物种的种子分离,具有显著的生物活动,包括抗炎,抗氧化剂和抗癌特性,使其成为药理学和生化研究兴趣的复合体. (E)-卡达莫宁因其调制关键信号路径(如NF-B和MAPK)的能力而进行了研究,有助于其潜在的治疗应用. 其明确界定的结构和高纯度使其适合用作分析研究的参考标准. 该化合物在普通有机溶剂中的稳定性和溶性进一步增强了其在实验环境中的效用.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号1070781-88-2 (2E)-1-[2-metho... | CAS号100-52-7 苯甲醛 | CAS号480-39-7 松属素; 乔松素 | CAS号111441-88-4 二乙酸松属素酯 | CAS号77-78-1 硫酸二甲酯 | CAS号1090-65-9 山姜素

合成工艺路线路线简述

    松属素置于吡啶,Potassium Carbonate体系中,化学反应生成小豆蔻明
    参考文献:Mahesh; Neelakantan; Seshadri,Journal Of Scientific And Industrial Research,1956,Vol. 15B,P. 287,290
    标题:Mahesh; Neelakantan; Seshadri,Journal Of Scientific And Industrial Research,1956,Vol. 15B,P. 287,290

    海关参考信息

    专利信息


    专利号:US-9061984-B2
    优先权日:2008-08-15
    标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases
    发明人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM
    权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS
    摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

    专利号:TW-201204250-A
    优先权日:2010-04-13
    标题:Method for the synthesis of substituted pyrrolines

    专利号:US-2015250175-A1
    优先权日:2012-10-01
    标 题:Pesticidally active mixtures comprising anthranilamide compounds
    发明人:KOERBER KARSTEN; WACH JEAN-YVES; KAISER FLORIAN; POHLMAN MATTHIAS; DESHMUKH PRASHANT; CULBERTSON DEBORAH L; ROGERS W DAVID; GUNJIMA KOSHI; DAVID MICHAEL; BRAUN FRANZ JOSEF; LANGEWALD JUERGEN
    权利人:BASF SE
    摘要:The present invention relates to pesticidal mixtures comprising as active compoundsn 1) at least one pesticidally active anthranilamide compound of formula (I) nn n n n n n n n n n wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and k are as defined in the description;n nandn 2) at least one pesticidally active compound II selected from a group M comprising acteylcholine esterase inhibitors, GABA-gated chloride channel antagonists, sodium channel modulators, nicotinic acteylcholine receptor agonists/antagonists, allosteric nicotinic acetylcholine receptor activitaors, chloride channel activators, juvenile hormone mimics, homopteran feeding blockers, mit grow inhibitors, inhibitors of mitochondrial bATP synthase, uncouplers of the oxidative phosphorylation, inhibitors of the chitin biosynthesis, moulting disruptors, ecdyson receptor agonists, octamin receptor agonists, inhibitors of the MET, voltage-dependent sodium channel blockers, inhibitors of the lipid synthesis, ryanodine receptor modulators and other compounds as defined in the description, in synergistically effective amounts. nn The invention relates further to methods and use of these mixtures for combating and controlling insects, acarids or nematodes in and on plants, and for protecting such plants being infested with pests, especially also for protecting plant propagation material, such as seeds.

    专利号:US-8828907-B2
    优先权日:2009-03-25
    标题:Active ingredient combinations having insecticidal and acaricidal properties
    发明人:HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG
    权利人:HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG; BAYER CROPSCIENCE AG
    摘要:The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) n nin whichn nR 1 and A have the meanings given in the descriptionn nand, secondly, at least one further known active compound from the class of the chitin synthesis inhibitors, the molting hormone agonists or other classes, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids.

    专利号:WO-2007112843-A1
    优先权日:2006-03-29
    标 题:Active ingredient combinations with insecticidal properties
    发明人:HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; SCHENKE THOMAS; ANDERSCH WOLFRAM; THIELERT WOLFGANG
    权利人:BAYER CROPSCIENCE AG; HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; SCHENKE THOMAS; ANDERSCH WOLFRAM; THIELERT WOLFGANG
    摘要:The invention relates to novel active ingredient combinations containing at least one known compound of formula (I), in which R is defined as cited in the description, and at least one additional known active ingredient, for example from the class of benzoyl ureas or chitin synthesis inhibitors, or other classes. Said combinations are extremely suitable for controlling animal pests such as insects and/or mites.

    专利号:CN-106924193-A
    优先权日:2017-03-20
    标 题:A kind of high porosity dry powder inhaler carrier and its supersaturated synthesis method and application
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    主要参考文献


    1: de Oliveira Cabral C, Campos A, da Silva LM, Boeing T, de Andrade SF, Filho VC, Nesello LÂN. Gastroprotective potential of methanolic extract and dimethyl cardamonin from Campomanesia reitziana fruits in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Jun;390(6):661-666. doi: 10.1007/s00210-017-1369-0. Epub 2017 Apr 1. doi: 10.1039/c7fo00054e. doi: 10.1016/j.pharep.2016.11.002. Epub 2016 Nov 9. doi: 10.1016/j.ejphar.2016.12.020. Epub 2016 Dec 15. doi: 10.1016/j.jneuroim.2016.11.012. Epub 2016 Dec 1.
    6: Zhang J, Sikka S, Siveen KS, Lee JH, Um JY, Kumar AP, Chinnathambi A, Alharbi SA, Basappa, Rangappa KS, Sethi G, Ahn KS. Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer. Apoptosis. 2017 Jan;22(1):158-168. doi: 10.1007/s10495-016-1313-7. BMC Complement Altern Med. 2016 Nov 15;16(1):467.
    8: Voon FL, Sulaiman MR, Akhtar MN, Idris MF, Akira A, Perimal EK, Israf DA, Ming-Tatt L. Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats. Eur J Pharmacol. 2017 Jan 5;794:127-134. doi: 10.1016/j.ejphar.2016.11.009. Epub 2016 Nov 11. pii: E1145. doi: 10.3390/molecules21091145. doi: 10.1002/biof.1315. Epub 2016 Sep 1. doi: 10.1016/j.ebiom.2016.03.037. Epub 2016 Mar 31.

    合成参考文献


    参考文献:10.1016/j.molimm.2006.04.025
    摘要:Israf DA, Khaizurin TA, Syahida A, Lajis NH, Khozirah S. Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells. Mol Immunol. 2007 Feb;44(5):673–9. doi: 10.1016/j.molimm.2006.04.025.
    参考文献:10.1152/ajpheart.00533.2012
    摘要:Mureli S, Gans CP, Bare DJ, Geenen DL, Kumar NM, Banach K. Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling. American Journal of Physiology-Heart and Circulatory Physiology. 2013 Feb 15;304(4):H600–9. doi: 10.1152/ajpheart.00533.2012.
    参考文献:10.1002/pca.867
    摘要:Zhang Q, Myint A, Cui H, Ge X, Liu L, Chou G. Determination of cardamonin using a chemiluminescent flow-injection method. Phytochem Anal. 2005 Nov;16(6):440–5. doi: 10.1002/pca.867.
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