CAS: 18621-17-5; 1-Benzhydrylazetidin-3-Ol

上下游产品

1-二苯甲基氮杂环丁烷-3-酮 N-Benzhydryl 3-Azetidinone 40320-60-3
1-(二苯甲基氨基)-3-氯丙烷-2-醇 1-(Benzhydrylamino)-3-Chloropropan-2-Ol 63477-43-0
1-二苯甲基-3-甲烷磺酸氮杂环丁烷 1-Benzhydryl-3-Azetidinyl Methanesulfonate 33301-41-6
(1-Benzhydrylazetidin-3-yl) N-Phenylcarbamate

1-二苯甲基-3-甲烷磺酸氮杂环丁烷置于甲基溴化镁体系中,用 四氢呋喃,乙醚 用作溶剂,化学反应 1.5H,反应生成N-二苯甲基氮杂环丁烷-3-醇
参考文献: Guanidino-Substituted Quinazolinone Compounds As Mc4-R Agonists[fr] Composes De Quinazoline Substitues Par Guanidino Constituant Des Agonistes De Mc4-R
标题: Guanidino-Substituted Quinazolinone Compounds As Mc4-R Agonists[fr] Composes De Quinazoline Substitues Par Guanidino Constituant Des Agonistes De Mc4-R
摘要:提供了一系列含有胍基的小分子化合物,能够作为mc4-R激动剂.当这些化合物被给予受试者时,它们对治疗mc4-R介导的疾病是有用的.这些化合物具有结构ia,Ib和ic,其中变量的值在此定义.

专利信息

专利号:WO-2018108954-A1
优先权日:2016-12-12
标题 :Process for the preparation of 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol
发明人：GOSSELIN FRANCIS; LINGHU XIN
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Methods of making 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol 9, an intermediate useful for the synthesis of estrogen receptor modulating compounds are described.

专利号:US-8071788-B2
优先权日:2004-10-14
标题:Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide
发明人：BOFFELLI PHILIPPE; DELTHIL MICHEL; GRONDARD LUC; LAMPILAS MAXIME; MALPART JOEL; MUTTI STEPHANE; NAIT-BOUDA LAHLOU; REIKE-ZAPP JOERG
权利人:BOFFELLI PHILIPPE; DELTHIL MICHEL; GRONDARD LUC; LAMPILAS MAXIME; MALPART JOEL; MUTTI STEPHANE; NAIT-BOUDA LAHLOU; REIKE-ZAPP JOERG; SANOFI AVENTIS
摘要:The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5 -difluorophenyl)methylsulfonamide.

专利号:US-11180480-B2
优先权日:2017-10-17
标题:Synthesis of 4-aminopyrimidine compounds
发明人：COPMANS DAAN; MOHR AMANDINE; BONTEN MAURICE HUBERT; TORONTO DAWN
权利人:SENSORION
摘要:A process for manufacturing 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine of Formula (I):including starting from 6-chloro-2-isobutylpyrimidin-4-amine and tert-butyl azetidin-3-yl(methyl)carbamate, or another N-protected N-methylazetidin-3-amine, and performing the following steps: (a) coupling reaction of both compounds in dimethylsulfoxide in presence of potassium carbonate to afford an intermediate protected compound; and (b) deprotection of the protected compound to afford 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine. Also, a process for manufacturing the intermediate protected compound, wherein deprotection step (b) is omitted, and the compounds obtained from the processes.

专利号:EP-3697776-A1
优先权日:2017-10-17
标 题:Synthesis of 4-aminopyrimidine compounds

专利号:WO-2019076974-A1
优先权日:2017-10-17
标 题:SYNTHESIS OF 4-AMINOPYRIMIDINE COMPOUNDS

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.