CAS: 185066-37-9; 4-(4'-(Hydroxy(Diphenyl)Methyl)Piperidin-1-yl)-1-(4-Isopropylphenyl)Butan-1-Ol

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1-(4-(Iso-Propyl)Phenyl)-4-(4-(Hydroxydiphenylmethyl)Piperidin-1-yl)Butan-1-One 185066-40-4
α,α-二苯基-4-哌啶甲醇 Azacyclonol 115-46-8

合成工艺路线路线简述

    📜α,α-二苯基-4-哌啶甲醇置于sodium Tetrahydroborate,Potassium Hydrogencarbonate体系中,用 甲醇,5,5-Dimethyl-1,3-Cyclohexadiene,水 用作溶剂,化学反应 12.5H,反应生成非索非那定杂质c
    参考文献:Novel And Efficient Method For The Synthesis Of Racemic Fexofenadine
    标题:Novel And Efficient Method For The Synthesis Of Racemic Fexofenadine
    摘要:[image Omitted] Fexofenadine Is A Selective H1-Histamine Receptor Antagonist,Which Is An Attractive Alternative Treatment For Allergy Symptoms. An Efficient And Environmentally Friendly Synthetic Approach For The Preparation Of Fexofenadine Was Developed From Commercially Available Cumene. The Method Involves The Friedel-Craft'S Reaction,Substitution,Reduction,Bromination,And The Grignard Reaction.
    Doi:10.1080/00397911.2010.502986

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/jm5010682
    摘要:Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus. J Med Chem. 2014 Oct 23;57(20):8540–62.
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