CAS: 154825-96-4; Methyl 2-(4-(1-Hydroxy-4-(4-(Hydroxydiphenylmethyl)Piperidin-1-yl)Butyl)Phenyl)-2-Methylpropanoate

相似化合物

154477-55-1 479035-75-1 1187954-56-8

上下游产品

methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoate 18H21N°C18H21NO Methyl 2-[4-(1-hydroxy-4-chlorobutyl)phenyl]isobutyrate 2-methyl-2-phenylpropionic acidfexofenadine fexofenadine hydr°Chloride methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoate

📜Alpha,Alpha-二甲基苯乙酸置于盐酸,甲醇,Sodium Hydroxide,Sodium Tetrahydroborate,Lithium Aluminium Tetrahydride,三氯化铝,Jones Reagent,水,Potassium Carbonate,4-吡咯烷基吡啶,对甲苯磺酸,三乙胺,Potassium Iodide体系中,用 四氢呋喃,甲醇,二硫化碳,乙醚,N,N-二甲基甲酰胺,丙酮,甲苯,苯 用作溶剂,化学反应 48.83H,反应生成非索非那定甲酯
参考文献:羧基terfenadine(非索非那定)及其生物等位四唑类似物的新合成.
标题:羧基terfenadine(非索非那定)及其生物等位四唑类似物的新合成.
摘要:描述了基于α-卤代-烷基芳基酮到相应的取代的2-芳基链烷酸酯的转化的羧基特非那定(4)的新合成.据报道其两个生物等位四唑类似物的对映选择性合成以及初步的生物学结果.
Doi:10.1016/s0014-827X(99)00070-1

专利信息

专利号:US-7220884-B2
优先权日:2004-02-10
标 题 :Hydroaminomethylation of olefins
发明人：BRIGGS JOHN R; WHITEKER GREGORY T; KLOSIN JERZY
权利人:DOW GLOBAL TECHNOLOGIES INC
摘要:The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.

专利号:US-2013237709-A1
优先权日:2012-03-02
标题 :Intermediates useful for the synthesis of fexofenadine, processes for their preparation and for the preparation of fexofenadine

专利号:EP-0723958-A1
优先权日:1993-06-24
标 题:Synthesis of substantially pure terfenadine derivatives