CAS: 151539-52-5; (E)-3-(2-Bromo-4,5-Dimethoxyphenyl)Acrylic Acid

该化合物是一种有机化合物,其特点是其独特的结构,包括一种由溴和甲氧基组组成的肉酸脊柱,第二位有溴原子,第四和第五位有两种甲氧基组,这对其化学特性和反应作用有重大影响.该化合物一般在室温中呈现固态,在有机溶剂中可溶解,反映其疏水性.由于其结构特征,它可能表现出令人感兴趣的生物活动,使它成为医药化学的一个对象.甲氧基组可以加强其脂性,有可能影响其与生物膜的相互作用.此外,该化合物可能会发生多种化学反应,例如,由于在恶性酸混合物中存在双份联系,因此会发生电子哲学替代或核分裂性添加.

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CAS号141-82-2 丙二酸 | CAS号5392-10-9 6-溴藜芦醛 | CAS号60632-40-8 6-溴香兰素 | CAS号108-24-7 乙酸酐

合成工艺路线路线简述

    📜6-溴香兰素置于吡啶,氢氧化钾,溶剂黄146体系中,化学反应生成2-溴-4,5-二甲氧基肉桂酸
    参考文献:用碱性高锰酸钾溶液氧化3,4-二甲氧基肉桂酸和取代产物.
    标题:用碱性高锰酸钾溶液氧化3,4-二甲氧基肉桂酸和取代产物.
    摘要:
    Doi:10.1021/jo01182A006

    海关参考信息

    专利信息


    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-7002020-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

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    合成参考文献

    参考DOI号:10.1007/s11176-005-0377-9
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