CAS: 15115-58-9; 3-(2-Bromophenyl)Propionic Acid

上下游产品

CAS号7345-79-1 2-溴肉桂酸 | CAS号58380-12-4 2-[(2-溴苯基)甲基]-丙二酸 | CAS号105-53-3 丙二酸二乙酯 | CAS号3433-80-5 邻溴溴苄 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号6630-33-7 2-溴苯甲醛 | CAS号66192-11-8 2-(2-溴苄基)丙二酸二乙酯 | CAS号93098-67-0 Propanedioic ac... | CAS号95-46-5 2-溴甲苯 | CAS号637-59-2 1-溴-3-苯基丙烷 | CAS号1075-28-1 1-溴-2-(3-溴丙基)苯 | CAS号102145-14-2 1-benzyl-3,4-di... | CAS号122-97-4 3-苯丙醇 | CAS号52221-92-8 2-溴苯丙醇 | CAS号6729-50-6 2,3,4,5-四氢-1H-2... | CAS号66191-86-4 邻溴苯丙酸甲酯 | CAS号7216-22-0 2,3,4,5-四氢-1H-2-苯氮杂卓 | CAS号107408-16-2 邻溴苯丙醛 | CAS号104-52-9 3-苯基-1-氯丙烷

邻溴肉桂酸置于wilkinson'S Catalyst,氢气体系中,用 乙醇 用作溶剂,25.0 °C,344.73 Kpa 条件下,反应 45.0H,以94%的收率获得3-(2-溴苯基)丙酸
参考文献:Synthesis And Hydrogen Bonding Capabilities Of Biphenyl-Based Amino Acids Designed To Nucleate β-Sheet Structure
标题:Synthesis And Hydrogen Bonding Capabilities Of Biphenyl-Based Amino Acids Designed To Nucleate β-Sheet Structure
摘要:The Syntheses Of 3'-(Aminoethyl)-2-Biphenylpropionic Acid (1) And 2-Amino-3'-Biphenylcarboxylic Acid (2) Are Described. These Residues Were Designed To Nucleate Beta-Sheet Structure In Aqueous Solution When Incorporated Into Small,Amphiphilic Peptides In Place Of The Backbone Of The I + 1 And I + 2 Residues Of The Beta-Turn. N-Benzyl-3'-(2-(Benzylamido)Ethyl)-2-Biphenylpropamide (3) And N-Benzyl-(2-Benzylamido)-3'-Biphenylamide (4) Were Synthesized And Studied As Model Compounds To Investigate The Hydrogen-Bonding Capabilities Of Residues 1 And 2,Respectively. The X-Ray Crystal Structure Of 3 Indicates That A 13-Membered Intramolecular Hydrogen-Bonded Ring Is Formed,While The Remaining Amide Proton And Carbonyl Are Involved In Intermolecular Hydrogen Bonding. Infrared And Variable-Temperature NMR Experiments Indicate That,In Solution (Ch2Cl2),3 Exists As An Equilibrium Mixture Of The 13-And The 15-Membered Intramolecularly Hydrogen-Bonded Conformers With The 15-Membered Ring Conformer Being Favored. Amide 4 Was Shown To Exist In Solution (Ch2Cl2) As An Equilibrium Mixture Of The 11-Membered Intramolecular Hydrogen-Bonded Ring And A Nonbonded Conformation. No Contribution From The 9-Membered Hydrogen-Bonded Ring Conformation Was Observed. The X-Ray Crystal Structure Of 4 Indicated The Absence Of Intramolecular Hydrogen Bonding In The Solid State.
Doi:10.1021/jo952194K

专利信息

专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-2009099367-A1
优先权日:2006-03-06
标题 :Process for preparing a leukotriene antagonist
发明人：BESSA BELLMUNT JORDI; RAFECAS JANE LLORENC; PASTO AGUILA MIREIA; VERDAGUER ESPAULELLA XAVIER; GORDO CAMPON ESTHER
权利人:FARMAPROJECTS S A
摘要:Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:CN-105198692-B
优先权日:2015-09-24
标题:A method for asymmetric catalytic synthesis of (S) aromatic curcumene

专利号:US-9738661-B2
优先权日:2006-10-27
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; SUMMA VINCENZO; HARPER STEVEN; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.