专利号:US-5688941-A 优先权日:1990-07-27 标题:Methods of making conjugated 4' desmethyl nucleoside analog compounds 发明人:COOK PHILLIP DAN; TENG KELLY 权利人:ISIS PHARMACEUTICALS INC 摘要:Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnostic assays and as research reagents. Novel intermediates for the synthesis of the compounds are also provided.
专利号:US-7582457-B2 优先权日:1998-05-12 标 题 :Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis 发明人:DUNN-COLEMAN NIGEL S; GATENBY ANTHONY; VALLE FERNANDO 权利人:DU PONT; GENENCOR INTERNAT 摘要:Recombinant organisms are provided comprising genes encoding cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for the production of 1,3-propanediol from a variety of carbon substrates.
专利号:US-5608046-A 优先权日:1990-07-27 标题 :Conjugated 4'-desmethyl nucleoside analog compounds 发明人:COOK PHILLIP DAN; TENG KELLY 权利人:ISIS PHARMACEUTICALS INC 摘要:Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnostic assays and as research reagents. Novel intermediates for the synthesis of the compounds are also provided.
专利号:US-6320040-B1 优先权日:1990-07-27 标题:4-desmethyl nucleoside analogs and oligomers thereof 发明人:COOK PHILLIP DAN; TENG KELLY 权利人:ISIS PHARMACEUTICALS INC 摘要:Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnosis assays and as research reagents. Novel intermediates for the synthesis of the compounds are also provided.
专利号:US-9284581-B2 优先权日:2009-12-10 标题:Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol 发明人:BURGARD ANTHONY P; BURK MARK J; PHARKYA PRITI 权利人:BURGARD ANTHONY P; BURK MARK J; PHARKYA PRITI; GENOMATICA INC 摘要:A non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway includes at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme or protein expressed in a sufficient amount to produce 1,3-BDO. A method for producing 1,3-BDO that includes culturing the this non-naturally occurring microbial organism under conditions and for a sufficient period of time to produce 1,3-BDO.
专利号:US-2006246562-A1 优先权日:1998-05-12 标题:Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis
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合成参考文献
摘要:A405: Moras E, Hosack A, Watkins D, Rosenblatt DS: Mitochondrial vitamin B12-binding proteins in patients with inborn errors of cobalamin metabolism. Mol Genet Metab. 2007 Feb;90(2):140-7. Epub 2006 Sep 29.