CAS: 13803-65-1; Anhydrotetracycline Hydrochloride
该化合物是一种半合成四环环环衍生物,在生物化学和微生物研究中具有显著应用,其主要优势在于其稳定性和溶性,适合受控制的实验条件;该化合物与四环抑制蛋白紧密结合,有利于在分子生物学研究中对基因表现进行精确调节;此外,它与四环生物研究相比,其抗生素活动减少,将无意的微生物抑制作用减少到最低程度,允许选择性地用于遗传工程;盐的盐形式提高了溶解性和处理特性,确保实验室应用的一贯性能;该化合物在需要不具有基因表达系统的研究中特别有用.
- 英文名称Anhydrotetracycline Hydrochloride
- 中文名称乳糖
- IUPAC名称(4S,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide Hydrochloride
- 其它别名(4S,4AS,12AS)-4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-2-NAPHTHACENECARBOXAMIDE MONOHYDR°CHLORIDE; ANHYDROTETRACYCLINE HYDR°CHLORIDE; AnhydrotetracyclineHCl; Anhydrotetracycline hydr°Chloride, 'can be used as a secondary standard'; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydr°Chloride, (4S,4aS,12aS)-; (4s,4as,12as)-4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide monohydr°Chloride; 5A,6-ANHYDROTETRACYCLINEHYDR°CHLORIDE; Anhydrotetracycline hydr°Chloride,'can be used as secondary standard.'
- CAS编号13803-65-1
- MFCD编号:MFCD00151453
- EINECS号:893-173-4
- FDA UNII编号:OVG14H105R
- 分子式:C22H23ClN2O7分子量:462.88
- 产品CID: 593056
- 产品分类生物化工 → 糖类化合物 → 双糖
物理性质
MSDS等安全信息
上下游产品
CAS号4465-65-0 4-差向脱水四环素 | CAS号4465-65-0 4-差向脱水四环素合成工艺路线路线简述
海关参考信息
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2901220000-丙烯
2902600000-乙苯
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专利信息
专利号:US-2025034519-A1
优先权日:2022-03-30
标题:Hydrogelated cells
发明人：TAN CHEEMENG; CONTRERAS LLANO LUIS E; HU CHE-MING J
权利人:UNIV CALIFORNIA; ACADEMIA SINICA
摘要:Assembly of a synthetic polymer network inside cells is described that renders the cells incapable of dividing. The resulting cells can retain functions, including for example, cellular metabolism, motility, protein synthesis, and compatibility with genetic circuits. The cells can also acquire new abilities to resist stressors that otherwise kill natural cells.
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主要参考文献
1: Sabharwal S, Kishore K, Moorthy PN. Determination of tetracycline hydrochloride in presence of anhydrotetracycline by differential pulse polarography. J Pharm Sci. 1988 Jan;77(1):78-80. doi: 10.1002/jps.2600770115. 58(4):470-2. doi: 10.1002/jps.2600580418. 22(3):430-2. Chinese.
222:117179. doi: 10.1016/j.saa.2019.117179. Epub 2019 May 28.
174:43-47. doi: 10.1016/j.ecoenv.2019.02.063. Epub 2019 Feb 25. 28(9):1278-83. doi: 10.1002/bmc.3161. Epub 2014 Mar 12. 26(3):417-26. doi: 10.1016/s0731-7085(01)00416-2. 37(1):35-46. French. 102(49):1308-13. 61(4):615-7. doi: 10.1002/jps.2600610427. 21(11):1018-22. Russian. 32(9-10):696-702. German.
合成参考文献
参考文献:10.1021/acs.jmedchem.2c01629
摘要:Williford EE, DeAngelo CM, Blake KS, Kumar H, Lam KK, Jones KV, Tolia NH, Dantas G, Wencewicz TA. Structure-Based Design of Bisubstrate Tetracycline Destructase Inhibitors That Block Flavin Redox Cycling. J. Med. Chem. 2023 Mar 06;66(6):3917–33. doi: 10.1021/acs.jmedchem.2c01629.
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