CAS: 137945-48-3; (6Ar,10Ar)-1-Hydroxy-6,6-Dimethyl-3-(2-Methyloctan-2-yl)-6A,7,10,10A-Tetrahydrobenzo[c]Chromene-9-Carboxylic Acid

上下游产品

(6Ar,10Ar)-1-Acetoxy-6,6-Dimethyl-3-(2-Methyloctan-2-yl)-6A,7,10,10A-Tetrahydro-6H-Benzo[c]Chromene-9-Carboxylic Acid 137945-50-7
(6Ar,10Ar)-3-(1,1-Dimethyl-Heptyl)-6,6,9-Trimethyl-6A,7,10,10A-Tetrahydro-6H-Benzo[c]Chromen-1-Ol
O-叔-丁基羰基hu210 2,2-Dimethyl-Propionic Acid (6Ar,10Ar)-3-(1,1-Dimethyl-Heptyl)-1-Hydroxy-6,6-Dimethyl-6A,7,10,10A-Tetrahydro-6H-Benzo[c]Chromen-9-Ylmethyl Ester 113418-02-3
(6Ar,10Ar)-3-(1',1'-Dimethylheptyl)-δ8-Tetrahydrocannabinol 1-O-Acetate 61597-29-3
(6Ar,10Ar)-1-((Tert-Butyldimethylsilyl)Oxy)-6,6-Dimethyl-3-(2-Methyloctan-2-yl)-6A,7,10,10A-Tetrahydro-6H-Benzo[c]Chromene-9-Carboxylic Acid 137945-49-4
[(6Ar,10Ar)-1-(Tert-Butyl-Dimethyl-Silanyloxy)-3-(1,1-Dimethyl-Heptyl)-6,6-Dimethyl-6A,7,10,10A-Tetrahydro-6H-Benzo[c]Chromen-9-Yl]-Methanol 137945-53-0
2,2-二甲基-丙酸(6Ar,10Ar)-1-(叔-丁基-二甲基-硅烷氧基)-3-(1,1-二甲基-庚基)-6,6-二甲基-6A,7,10,10A-四氢-6H-苯并[c]色烯-9-基甲基酯 ((6Ar,10Ar)-1-((Tert-Butyldimethylsilyl)Oxy)-6,6-Dimethyl-3-(2-Methylctan-2-yl)-6A,7,10,10A-Tetrahydro-6H-Benzo[c]Chromen-9-yl)Methyl Pivalate 137945-54-1

📜2,2-二甲基-丙酸(6Ar,10Ar)-1-(叔-丁基-二甲基-硅烷氧基)-3-(1,1-二甲基-庚基)-6,6-二甲基-6A,7,10,10A-四氢-6H-苯并[c]色烯-9-基甲基酯置于吡啶,Chromium(Vi) Oxide,Sodium Chlorite,Potassium Dihydrogenphosphate,Lithium Aluminium Tetrahydride,2-甲基-2-丁烯,四丁基氟化铵,叔丁醇体系中,用 四氢呋喃,乙醚,二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 7.75H,反应生成(6Ar,10Ar)-1-羟基-6,6-二甲基-3-(2-甲基辛-2-基)-6A,7,10,10A-四氢苯并[c]色原烯-9-羧酸
参考文献:合成的非精神大麻素,具有有效的抗炎,止痛和白细胞抗粘连活性.
标题:合成的非精神大麻素,具有有效的抗炎,止痛和白细胞抗粘连活性.
摘要:设计治疗上有用的大麻素的两种策略已经结合在一起,以产生具有大大增强的抗炎活性并且具有较低的不良副作用可能性的化合物.已经合成了对映体大麻素,其在第7位具有一个羧酸基团,在第5'位具有一个伸长和分支的烷基侧链,并测试了其抗炎活性.当以10微克/千克的剂量口服给予时,它们可有效减少花生四烯酸或血小板活化因子诱导的小鼠爪水肿.在以与爪水肿试验相同的剂量范围内口服给予大麻素的小鼠的腹膜细胞中,白细胞对培养皿的粘附也降低了.在小鼠热板试验中可以观测到抗伤害作用.然而,与上述测试相反,几乎没有立体化学偏好,在上述测试中,3R,4R化合物比3S,4S对映体活性更高.最后,与早先有关天然戊基侧链酸的报道相一致,合成酸在小鼠中产生僵直的作用很小,这表明它们在人类中是非精神病的.
Doi:10.1021/jm00095A007

专利信息

专利号:WO-2024227949-A1
优先权日:2023-05-04
标 题:Screening and uses of glutamine synthetase modulators
发明人：MARTINS GARCIA BRUNA; FARAH PERNAS LENA
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to an in vitro bioassay to identify glutamine synthetase activators and inhibitors on the basis of one or more glutamine markers such as citrate, a metabolite derived from the mevalonate pathway, a glutamine responsive mRNA or proteins, such as HMGCR or SREBP2. Disclosed herein are also glutamine synthetase activators and inhibitors identified by the inventive method for use to stimulate or inhibit the synthesis of a metabolite derived from the mevalonate pathway, such as cholesterol, and to treat a disease associated with deregulated levels of said metabolite, such as cancer.

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:US-8138174-B2
优先权日:2007-01-10
标 题:Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; SOLVAY PHARM BV
摘要:Compounds with a combination of cannabinoid CB 1 antagonism and serotonin reuptake inhibition, pharmaceutical compositions containing these compounds, methods for preparing these compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing these compositions are disclosed. Uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders are disclosed. n In at least one embodiment, the invention relates to compounds of the general formula (1): n nwherein the substitutents have the definitions given in the specification.

专利号:US-2025049735-A1
优先权日:2021-12-06
标题:Medicine for steatohepatitis
发明人：HAYASHI HISAMITSU; SABU Yusuke; TAMURA RYUTARO
权利人:UNIV TOKYO
摘要:It is an object of the present invention to provide a preventive agent, a therapeutic agent or a therapeutic composition for steatohepatitis developed by phospholipid deficiency or decreased phospholipid synthesis in the liver, and to provide a therapeutic method for the aforementioned disease. More specifically, the present invention relates to a therapeutic agent for steatohepatitis, comprising, as an active ingredient, choline or a choline metabolite, ethanolamine or an ethanolamine metabolite, a salt thereof, or a solvate thereof, wherein the therapeutic agent for steatohepatitis is characterized in that the steatohepatitis is developed by decreased phospholipid synthesis in the liver. Examples of the choline metabolite may include betaine, dimethylglycine, and phosphatidylcholine.

专利号:US-11371068-B2
优先权日:2017-12-12
标 题:Extracellular heme production method using metabolically engineered microorganism
发明人：LEE SANG YUP; Zhao xin rui; CHOI KYEONG ROK
权利人:KOREA ADVANCED INST SCI & TECH
摘要:The present invention relates to a microorganism variant having the ability to extracellularly produce heme, and more particularly to a metabolically engineered microorganism variant having the ability to extracellularly produce heme and a method of producing heme using the same. According to the present invention, heme, an organometallic compound which is increasingly used as a health food or food supplement for the treatment of porphyria , can be extracellularly secreted and produced in high yield using the microorganism variant, but not conventional chemical synthesis or enzymatic synthesis.

专利号:CN-113845410-B
优先权日:2021-10-29
标题 :Synthesis method of magnolol derivatives and intermediates