CAS: 1228779-96-1; 3-Nitro-4-(((Tetrahydro-2H-Pyran-4-yl)Methyl)Amino)Benzenesulfonamide

相似化合物

1271003-71-4 1220018-84-7 1219957-13-7

上下游产品

3-硝基-4-氯苯磺酰胺 4-Chloro-3-Nitrobenzenesulfonamide 97-09-6
4-氟-3-硝基苯磺酰胺 4-Fluoro-3-Nitrobenzenesulfonamide 406233-31-6

硝基氯苯置于氯磺酸,N,N-二异丙基乙胺体系中,用 乙腈 用作溶剂,化学反应 48.0H,反应生成3-硝基-4-[[(四氢吡喃-4-基)甲基]氨基]苯磺酰胺
参考文献: Process For The Preparation Of Venetoclax[fr] Procédé De Préparation De Vénétoclax
标题: Process For The Preparation Of Venetoclax[fr] Procédé De Préparation De Vénétoclax

专利信息

专利号:EP-4421075-A1
优先权日:2023-02-27
标 题 :Process for the preparation of venetoclax and intermediates used therein
发明人：BERGANT SIMONCIC ANA
权利人:KRKA D D NOVO MESTO
摘要:The invention relates to a process for the synthesis of Venetoclax. The invention further relates to intermediates that are useful in the synthesis of Venetoclax.

专利号:EP-3412666-A1
优先权日:2017-06-07
标 题:Process and intermediates for the preparation of bcl-2 inhibitors including venetoclax through reductive amination
发明人：GREGG BRIAN THOMAS; GEISS WILLIAM BERT; HERR ROBERT JASON
权利人:ALBANY MOLECULAR RES INC
摘要:The invention relates to a process for the preparation of compounds of formula (I), which are useful intermediates in the synthesis of Venetoclax and structurally related compounds, by reductive amination of a compound of formula (II).

专利号:US-2022073513-A1
优先权日:2018-12-29
标题:1h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to compounds of Formula (II) and more preferably to 1H-pyrrolo[2,3-b]pyridine derivatives of formula (III) and related compounds. The variables are defined in the claims. The compounds are BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis of exemplary compounds as well as pharmacological data thereof (pages 61 to 72; examples 1 to 4; tables). An exemplary compound is e.g. 4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-2-[methyl(1H-pyrrolo[2,3-b]pyridin-5-yl)phosphoroso]-N-[3-nitro-4-[(oxan-4-yl methyl)amino]benzenesulfonyl]benzamide (example 1).

专利号:US-2023119463-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

专利号:WO-2021133817-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:GUANGZHOU LUPENG PHARMACEUTICAL COMPANY LTD; NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).